myeloproliferative disease Single-Cell Analysis Elucidates Mutation Patterns in Myeloid Malignancies Researchers combined protein expression with mutational analysis to map the somatic genotype and clonal architecture of AML with its immunophenotype. Single-Cell Method Could Eliminate Need for Mouse Models to Study Cancer Treatment Resistance Premium The method allows for the annotation of cells by their genotype and capture of single-cell transcriptomes, even when the cells aren't morphologically distinct. Acute Myeloid Leukemia Analysis Brings Together Integrated Omic, Drug Response Profiles Members of the Beat AML consortium uncovered relationships between somatic mutations, gene expression profiles, and sensitivity to more than 100 drugs. Myeloproliferative Neoplasms Fall Into Genetic Subgroups With Distinct Clinical Phenotypes In combination with other clinical data, the genomic subtypes were able to predict patients' outcomes and could be used to help guide treatments. AMP Report Recommends Genes for Chronic Myeloid Neoplasm Sequencing Panels The working group reviewed data to identify a minimum of 34 commonly mutated genes that should be included in pan-myeloid targeted panels. Jan 23, 2018 Qiagen JAK2 Test Gets FDA Clearance for Additional Blood Cancer Types Mar 30, 2017 Qiagen Gets FDA Clearance for JAK2 Assay to Help Diagnose Blood Cancer Type Jun 8, 2016 DNA Sequencing Illuminates 11 Genetic Subtypes of AML Premium Apr 8, 2015 GWAS Reveals Loci Linked to Myeloproliferative Neoplasm Risk Feb 11, 2015 Mutation Order May Impact Clinical Outcome of Myeloproliferative Neoplasms Premium Nov 19, 2014 Dana-Farber, Brigham and Women's Develop NGS Panel for Rapid Diagnosis of Hematologic Cancers Premium Sep 8, 2011 Dx Focus Sep 8, 2011: Clinical and Regulatory PCR and Nucleic Acid Testing News Premium Sep 7, 2011 Qiagen, Lilly Partner to Develop JAK2 Companion Test for Investigational Blood Cancer Drug Premium Jul 19, 2011 Univ. of Cambridge Lands $6.3M for Blood Cancer Study Jun 16, 2011 Qiagen to Expand QIASymphony RGQ Test Menu with Ipsogen Buy Premium Breaking News SARS-CoV-2 Variants of Concerns Evolved to Modify Host Immune Response, Multiomics Study Shows People in the News at GA4GH, Mercy BioAnalytics, Deepcell, One Biosciences New Products Posted to GenomeWeb: Clinical Microbiomics, Integra Biosciences, DNAstack, Bruker Angolan Namib Desert Population Analysis Uncovers New Ancestry Group With Deep Divergence Cedars-Sinai Sets Up $25M Single Cell Precision Medicine Center The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.