myeloproliferative disease
Genetic Variant in South American Indigenous Population Linked to Better Blood Cancer Drug Response
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The variant, present in the NFKB1 gene and common in the Aymara community, could help guide treatment decisions, researchers reported at ASH.
Single-Cell Analysis Elucidates Mutation Patterns in Myeloid Malignancies
Researchers combined protein expression with mutational analysis to map the somatic genotype and clonal architecture of AML with its immunophenotype.
Single-Cell Method Could Eliminate Need for Mouse Models to Study Cancer Treatment Resistance
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The method allows for the annotation of cells by their genotype and capture of single-cell transcriptomes, even when the cells aren't morphologically distinct.
Acute Myeloid Leukemia Analysis Brings Together Integrated Omic, Drug Response Profiles
Members of the Beat AML consortium uncovered relationships between somatic mutations, gene expression profiles, and sensitivity to more than 100 drugs.
Myeloproliferative Neoplasms Fall Into Genetic Subgroups With Distinct Clinical Phenotypes
In combination with other clinical data, the genomic subtypes were able to predict patients' outcomes and could be used to help guide treatments.