myeloproliferative disease
Single-Cell Analysis Elucidates Mutation Patterns in Myeloid Malignancies
Researchers combined protein expression with mutational analysis to map the somatic genotype and clonal architecture of AML with its immunophenotype.
Single-Cell Method Could Eliminate Need for Mouse Models to Study Cancer Treatment Resistance
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The method allows for the annotation of cells by their genotype and capture of single-cell transcriptomes, even when the cells aren't morphologically distinct.
Acute Myeloid Leukemia Analysis Brings Together Integrated Omic, Drug Response Profiles
Members of the Beat AML consortium uncovered relationships between somatic mutations, gene expression profiles, and sensitivity to more than 100 drugs.
Myeloproliferative Neoplasms Fall Into Genetic Subgroups With Distinct Clinical Phenotypes
In combination with other clinical data, the genomic subtypes were able to predict patients' outcomes and could be used to help guide treatments.
AMP Report Recommends Genes for Chronic Myeloid Neoplasm Sequencing Panels
The working group reviewed data to identify a minimum of 34 commonly mutated genes that should be included in pan-myeloid targeted panels.
Jun 8, 2016
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