myelodysplastic syndrome

Individuals with higher-than-usual mutant allele frequencies after stem cell transplantation were prone to disease progression and reduced progression-free survival.

The working group reviewed data to identify a minimum of 34 commonly mutated genes that should be included in pan-myeloid targeted panels.

Researchers identified mutations present prior to allogeneic hematopoietic stem cell transplantation that coincided with MDS survival and relapse.

The firm said its Focus::Myeloid NGS-based panel for myeloid malignancies provides information for diagnosis, prognosis, treatment, and risk stratification of patients.

The study expands on the known genetic subtypes, shows that they are correlated with clinical outcome, and paves the way for better subtype-driven patient management. 

This Week in PNAS

In PNAS this week: decreased DOCK4 expression in myelodysplastic syndromes plus anemia, hepatitis A evolution, and more.

Researchers sequenced samples from hundreds of individuals with aplastic anemia to narrow in on somatic mutation and clonal evolution patterns in the disease.

The 95-gene test is for detecting leukemia, myelodysplastic syndromes, and myeloproliferative disorders and can return results in less than one week.

NEW YORK (GenomeWeb) – Moffitt Cancer Center and M2Gen today said they have been awarded a seven-year, $7.3 million contract from the National Heart, Lung, and Blood Institute to coordinate a central laboratory and biorepository for research into myelodysplastic syndromes.

NEW YORK (GenomeWeb) – Cancer Genetics today announced a collaboration with Columbia University researchers to identify more accurate diagnostic and prognostic biomarkers for myelodysplastic syndromes.

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An Australian-led team has generated a draft genome assembly of the invasive cane toad in hopes it will help in population control, the Sydney Morning Herald reports.

The New York Times reports that the US Department of Defense has implemented about half the recommendations made to improve safe handling of dangerous agents.

In PLOS this week: approach for teasing out archaic introgression in human genomes, immune transcription features in HCV infection, and more.

Stat News reports that Maryland is promoting itself to the biotech industry with a mobile billboard.