myelodysplastic syndrome

A new analysis suggests that some mutations that seem to occur in tumors might actually stem from infiltrating blood cells affected by myeloproliferative neoplasms.

Individuals with higher-than-usual mutant allele frequencies after stem cell transplantation were prone to disease progression and reduced progression-free survival.

The working group reviewed data to identify a minimum of 34 commonly mutated genes that should be included in pan-myeloid targeted panels.

Researchers identified mutations present prior to allogeneic hematopoietic stem cell transplantation that coincided with MDS survival and relapse.

The firm said its Focus::Myeloid NGS-based panel for myeloid malignancies provides information for diagnosis, prognosis, treatment, and risk stratification of patients.

The study expands on the known genetic subtypes, shows that they are correlated with clinical outcome, and paves the way for better subtype-driven patient management. 

This Week in PNAS

In PNAS this week: decreased DOCK4 expression in myelodysplastic syndromes plus anemia, hepatitis A evolution, and more.

Researchers sequenced samples from hundreds of individuals with aplastic anemia to narrow in on somatic mutation and clonal evolution patterns in the disease.

The 95-gene test is for detecting leukemia, myelodysplastic syndromes, and myeloproliferative disorders and can return results in less than one week.

NEW YORK (GenomeWeb) – Moffitt Cancer Center and M2Gen today said they have been awarded a seven-year, $7.3 million contract from the National Heart, Lung, and Blood Institute to coordinate a central laboratory and biorepository for research into myelodysplastic syndromes.

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A University of California, Los Angeles-led team has found turning off the CCR5 gene could improve recovery after a stroke, according to Scientific American.

South Dakota lawmakers are to weigh a bill aimed at teaching the strengths and weaknesses of scientific concepts, the Associated Press and KEVN-Black Hills Fox report.

In Science this week: the synthetic genetic system hachimoji, and more.

Thermo Fisher Scientific says it will no longer sell machines in China's Xinjiang region, according to the Wall Street Journal.