myelodysplastic syndrome WUSTL Expands Patient Pool for WGS Cancer Test After CMS Coverage Milestone Premium The high-coverage whole-genome assay is covered for patients with myeloid neoplasms, including acute myeloid leukemia and myelodysplastic syndrome. Optical Genome Mapping Gains Momentum for Clinical Applications in Hematologic Disorders Premium MD Anderson Cancer Center researchers demonstrated the prognostication utility of optical genome mapping in myelodysplastic syndromes patients. Whole-Genome Sequencing Could Replace Cytogenetics in Assessing AML, Myelodysplastic Syndromes The researchers found that sequencing was accurate and could even detect chromosomal changes missed by cytogenetics at almost a similar price. Clinicians Face New Intervention Questions as Clonal Hematopoiesis Mutation Data Evolves Premium Increased incidental detection of clonal hematopoiesis and new considerations for mutations in myelodysplastic precursors herald improved precision medicine strategies. MSK Clonal Hematopoiesis Clinic Aims to Drive New Strategies for Cancer Risk Assessment, Prevention Premium The program is in its third year monitoring individuals with these mutations to try to detect disease early, understand their risk, and develop preventive treatments. Jul 10, 2020 Study Spells Out Immune, Genomic, Epigenomic Interactions in Hematological Malignancies Aug 12, 2019 Mission Bio, Onconova Therapeutics Sign Cancer Therapy Research Partnership Aug 8, 2019 Dominant-Negative Effect Detected for Missense TP53 Mutations in Myeloid Cancers Jul 17, 2019 Cancer Drug Discovery Firm Notable Nabs $40M in Series B Funding Round Jan 3, 2019 Tumor Sequencing May Pick Up Mutations Caused by Coexistent Blood Disorder Sep 13, 2018 Myelodysplastic Syndrome Progression Informed by Post-Treatment Mutation Sequencing Aug 22, 2018 AMP Report Recommends Genes for Chronic Myeloid Neoplasm Sequencing Panels Feb 9, 2017 Myelodysplastic Syndrome Mutations Offer Prognostic Hints for Stem Cell Transplant Patients Aug 17, 2016 Cancer Genetics Receives NY State Approval for NGS-Based Cancer Panel Jun 8, 2016 DNA Sequencing Illuminates 11 Genetic Subtypes of AML Premium Jul 2, 2015 Sequencing Offers Clues to Clonal Evolution in Aplastic Anemia Nov 19, 2014 Dana-Farber, Brigham and Women's Develop NGS Panel for Rapid Diagnosis of Hematologic Cancers Premium Nov 5, 2014 NHLBI Awards $7.3M Contract to Moffitt, M2Gen to Coordinate Lab, Biorepository for MDS Study Oct 13, 2014 Cancer Genetics, Columbia Researchers Collaborate on MDS Biomarkers Sep 10, 2013 EU Blueprint Effort to Fund Epigenetic Biomarker Projects Jun 25, 2012 RainDance, MLL Collaborate on Leukemia Panel Jul 27, 2011 Sequencing/Genotyping Combination Yields Somatic Mutations with Prognostic and Dx Potential in MDS Premium Oct 15, 2010 Stanford Researchers Use Nano-Immunoassay to Study Protein Phosphoisoforms Related to Cancer Premium Breaking News Compact Gene Editing Enzyme May Improve Success Rates of Gene Therapies People in the News at Veracyte, Invitae, Mount Sinai, InterVenn Biosciences, Applied BioCode, More New Products Posted to GenomeWeb: Qiagen, IDT, Revvity, Mission Bio, NRichDx, More FDA Releases Proposed Rule for Oversight of Laboratory-Developed Tests CStone Pharmaceuticals, Genetron Companion Diagnostic Receives NMPA Approval The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.