In Science this week: epigenetic memory of environmental changes in roundworms, and more.
Incorporating splicing and other clues from muscle transcripts, researchers reached diagnoses in cases that were inconclusive after sequencing alone.
Exonics will use the funding to advance preclinical research from UT-Southwestern researcher Eric Olson on genome editing of DMD mutations in a mouse model.
UT-SWMC researcher Eric Olson will study dystrophin produced with CRISPR/Cas9 genome editing in a mouse model, as well as off-target effects.
While gain-of-function mutations lead to congenital arhinia, inactivating mutations lead to an adult-onset muscular dystrophy, the researchers reported.
The company's Irys genome mapping technology provides researchers with a non-sequencing-based tool that is essential for studying structural variation.
The grant from the California Institute of Regenerative Medicine will fund research on two approaches to DMD gene therapy using CRISPR/Cas9.
The agreement gives CRISPR Therapeutics access to a technology to create skeletal muscle stem cells for use in research on Duchenne Muscular Dystrophy.
Researchers have found that mutations linked with laminopathies disrupt epigenomic developmental programs.
In exome sequence data for individuals with limb-girdle muscular dystrophy, researchers identified individuals carrying more than one pathogenic mutation.
The World Health Organization has announced the members of its gene-editing committee, according to NPR.
DARPA is working on developing algorithms that gauge the credibility of research findings, Wired reports.
The American Society of Breast Surgeons recommends all women diagnosed with breast cancer be offered genetic testing, the Washington Post says.
In Science this week: comparison of modern, historical rabbit exomes uncovers parallel evolution after myxoma virus exposure; and more.