Using brain samples from individuals with or without multiple sclerosis, researchers detected declining projection neuron levels and related immune cell shifts.
The researchers plan to analyze clinical records and genetic data from whole-exome sequencing for more than 3,000 patients using DNAnexus' Apollo platform.
In PLOS this week: map of breakpoints in individuals with complex chromosomal rearrangements, sequence of virus that infects African armyworm, and more.
In a meta-analysis of nearly 70,000 individuals, researchers estimated that low-frequency coding variants contribute about 5 percent of multiple sclerosis risk.
A team led by the University of British Columbia homed in on a variant that linked to increased liver enzyme levels and liver injury during interferon-β treatment.
A large meta-analysis and functional genomic assessment of a risky HLA haplotype uncovered hypomethylation that alters immune-related expression at the locus.
A genetic analysis of salmon scales collected over the course of a century points to a sharp decline in the number of fish returning each year to river in British Columbia, CBC reports.
