MS

Two alleles work together to influence multiple sclerosis risk, a Duke University-led team has found.

MS Paper Critiqued

Researchers are criticizing a paper linking a rare gene variant to multiple sclerosis, Stat News reports.

A Winthrop-University Hospital team showed that demethylated circulating cell-free DNA from dying oligodendrocytes is a biomarker for relapsing-remitting MS.

Certain bacterial species appear more common in gut microbiomes of individuals with MS, coinciding with inflammation-related gene expression in host blood.

Researchers uncovered four new multiple sclerosis susceptibility loci through a genome-wide association study, and linked them to epigenetic regulation.

The research team linked a mutation in a protein-coding gene to inherited multiple sclerosis and genetic risk factors for developing the disease. 

IQuity's current tests analyze gene expression patterns detected in mRNA, but the firm is also exploring the diagnostic potential of long non-coding RNAs.

The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.

With the help of a newly generated gene regulatory network for T-cell differentiation, researchers identified transcription factors with ties to disease symptoms.

Regulus said it was able to develop its miRNA extraction and profiling technology to meet the quality specifications set out by its partner.

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Dog DNA testing finds that some purebreds might not truly be purebreds, Inside Edition reports.

Mary Beckerle has returned as director of the Huntsman Cancer Institute, according to ScienceInsider.

Smithsonian Magazine reports that environmental DNA sampling can be used to track elusive organisms.

In Genome Research this week: repetitive satellite DNA in the fruit fly, transcriptome map assembly pipeline, and more.