MS

The firm's recent funding round will support its CLIA-certified laboratory that opened last year and the launch of its first RNA-based diagnostic test.

This Week in Science

In Science this week: a protective gene in C. elegans, and combining EHRs with genetic data to ID HLA-associated variants

Two alleles work together to influence multiple sclerosis risk, a Duke University-led team has found.

MS Paper Critiqued

Researchers are criticizing a paper linking a rare gene variant to multiple sclerosis, Stat News reports.

A Winthrop-University Hospital team showed that demethylated circulating cell-free DNA from dying oligodendrocytes is a biomarker for relapsing-remitting MS.

Certain bacterial species appear more common in gut microbiomes of individuals with MS, coinciding with inflammation-related gene expression in host blood.

Researchers uncovered four new multiple sclerosis susceptibility loci through a genome-wide association study, and linked them to epigenetic regulation.

The research team linked a mutation in a protein-coding gene to inherited multiple sclerosis and genetic risk factors for developing the disease. 

IQuity's current tests analyze gene expression patterns detected in mRNA, but the firm is also exploring the diagnostic potential of long non-coding RNAs.

The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.

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The president of France's National Research Agency has resigned, according to Nature News.

A senator wants a "right-to-try" provision in the US Food and Drug Administration funding bill, but an ethicist says at Stat News that it would undermine the role of clinical trials.

In PNAS this week: red algae Porphyra umbicalis genome, deep neural network model for sequencing peptides, and more.

The Guardian's Barbara Ellen has tried out some DNA testing services to see whether they provide valuable information.