mitochondrial disease Researchers Achieve Targeted A-to-G Base Editing in Human Mitochondrial DNA Premium The technology can in principle correct almost half of pathogenic mtDNA mutations, paving the way for mitochondrial disease modeling and therapeutic applications. Mitochondrial Protein Resource Reveals New Disease Players Researchers developed a "mitochondrial orphan protein multi-omics" (MITOMICS) app by profiling proteins, lipids, and metabolites in cells lacking individual mitochondrial proteins. Free Mitochondrial Disease Genetic Testing Program Established by Zogenix, Others The patient-initiated program is available to anyone in the US suspected of having mitochondrial disease. Bacterial Toxin Leads to CRISPR-Free Mitochondrial DNA Base Editing Unlike previously described cytidine deaminases, Mitochondrial DNA Can Be Paternally Inherited in Humans, New Study Finds Researchers have uncovered three families in which individuals inherited mitochondrial DNA from their fathers, upending existing belief. Sep 25, 2018 Researchers Use ZFNs to Edit Mutation in Mitochondrial DNA In Vivo Jul 31, 2017 Genetic Testing Evaluated For Diagnosing Epilepsy, Monogenic Conditions Sep 16, 2016 Courtagen, Astellas Partner on Mitochondrial Disease Drug Development Aug 5, 2016 Three Newly Identified Mitochondrial Proteins May Play Role in Disease Aug 3, 2016 Newcastle University Lab Converts Sanger Tests to NGS Test for Mitochondrial Disorder Premium Mar 22, 2016 Tute Genomics, UNIConnect Ink Deal With Newborn Screening Ontario Sep 23, 2015 UAB Heads Partnership Focusing on Patient Care for Mitochondrial Diseases Jul 15, 2015 Courtagen Raises $20M Jun 17, 2015 Courtagen Raises $7.5M Apr 23, 2015 Courtagen Inks Distribution Deals for Israel, Thailand Apr 23, 2015 Salk Scientists Develop Method to Edit Mutations in Germline Mitochondrial DNA Premium Mar 25, 2014 Courtagen to Provide Genetic Profiling for Raptor's Mitochondrial Disorder Drug Trial Jul 30, 2012 Transgenomic Teams With MCW to Offer NGS Testing Services Mar 21, 2012 Baylor, Arup Turn to Next-Gen Sequencing to Address Challenges of Mitochondrial Disease Diagnosis Premium Feb 29, 2012 New Products: GeneDx's Mito101 Premium Oct 19, 2011 Dutch Study Aims to Demonstrate Cost-Effectiveness of Reimbursing for Exome Sequencing Dx Premium Jun 21, 2011 Transgenomic Launches NGS-Based Mitochondrial Disease Test, Developing Autism Risk Test Premium Apr 12, 2011 Medomics Raises Funds to Grow its Sequencing-Based Tests for Mitochondrial Disease Premium Sep 7, 2010 Gene Prediction and Targeted Sequencing Detect Causal Mutations in Complex Mitochondrial Disease Premium Mar 6, 2009 Transgenomic Gets California OK for Clinical Lab Load More Breaking News Gut Microbiome Characteristics Tied to Depressive Symptoms in New Studies Bluestar Genomics to Study Pancreatic Cancer Early Detection Test in Type 2 Diabetes Patients Cowen Upgrades PerkinElmer Stock to Outperform CareDx to Repurchase up to $50M of Common Stock European Commission Outlines Intended Restorative Measures for Blocked Illumina-Grail Deal The Scan Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan. Lupus Heterogeneity Highlighted With Single-Cell Transcriptomes Using single-cell RNA sequencing, researchers in Nature Communications tracked down immune and non-immune cell differences between discoid lupus erythematosus and systemic lupus erythematosus. Rare Disease Clues Gleaned From Mobile Element Insertions in Exome Sequences With an approach called MELT, researchers in the European Journal of Human Genetics uncovered mobile element insertions in exomes from 3,232 individuals with or without developmental or neurological abnormalities. Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.