medulloblastoma
New Mutations Identified in Common Childhood Brain Cancers Could Guide Personalized Treatments
In a study published in PNAS, Swedish researchers identified new mutations implicated in common pediatric cancers in the noncoding regions.
Medulloblastoma Long-Read Sequences Reveal Complex Rearrangements, Methylation Changes
With Oxford Nanopore sequencing, researchers found DNA methylation clues and complex rearrangement patterns that were subsequently assessed in a broader cancer set.
Medulloblastoma Molecular Studies Point to Cell Origins, Progenitor Differentiation
A pair of studies suggest group 3 and group 4 medulloblastoma subtypes stem from alterations affecting the unipolar brush cell lineage in the developing brain's rhombic lip region.
Pediatric Medulloblastoma Subgroups May Benefit from Lower-Dose Radiation Therapy
The study found certain patients did not benefit from lower doses of radiation therapy, suggesting the need for molecular selection.
Cancer Researchers Discover Novel Inherited Mutation Predisposing Children to Medulloblastoma
The researchers identified rare germline loss-of-function variants across the ELP1 gene in 14 percent of pediatric patients in a medulloblastoma subgroup.