medulloblastoma

An international team found that survival estimates differed significantly between patients with germline mutations in different medulloblastoma predisposition genes.

This Week in Nature

In Nature this week: investigation into the genetics of medulloblastoma, and more.

With mutation, expression, and epigenetic features from hundreds of medulloblastoma tumors, researchers characterized key features of brain tumor subtypes.

A multi-region analysis of medulloblastoma and other tumor types highlighted the dramatic somatic alteration differences that can crop up within a single tumor.

The team also potentially identified the cells of origin for the most common medulloblastoma subtype, which could help develop novel therapeutics. 

Researchers have found that mutations present in medulloblastoma tumors at relapse differ substantially from those present at diagnosis.

COLD SPRING HARBOR, NY (GenomeWeb News) – Through whole-exome sequencing of single cells from a medulloblastoma tumor, researchers were able to identify distinct cancer cell types within the tumor that otherwise may have been overlooked, work presented by Stanford University's Sofia Kyriazopoulou

NEW YORK (GenomeWeb News) – Three genomic studies published in Nature this week are expanding understanding of the mutations and structural variations that define the four subtypes of medulloblastoma, a childhood brain cancer.

The Hospital for Sick Children and the Michael Smith Genome Sciences Center are conducting a whole-genome sequencing study of 1,000 pediatric brain cancer tumors.

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Sometimes genetic tests give inconclusive results and provide little reassurance to patients, the Associated Press reports.

Vox wonders whether gene-editing crops will be viewed similarly as genetically modified organisms of if people will give them a try.

In Science this week: research regulation and reporting requirement reform, and more.

With H3Africa, Charles Rotimi has been working to bolster the representation of African participants and African researchers in genomics, Newsweek reports.