medulloblastoma New Mutations Identified in Common Childhood Brain Cancers Could Guide Personalized Treatments In a study published in PNAS, Swedish researchers identified new mutations implicated in common pediatric cancers in the noncoding regions. Medulloblastoma Long-Read Sequences Reveal Complex Rearrangements, Methylation Changes With Oxford Nanopore sequencing, researchers found DNA methylation clues and complex rearrangement patterns that were subsequently assessed in a broader cancer set. Medulloblastoma Molecular Studies Point to Cell Origins, Progenitor Differentiation A pair of studies suggest group 3 and group 4 medulloblastoma subtypes stem from alterations affecting the unipolar brush cell lineage in the developing brain's rhombic lip region. Pediatric Medulloblastoma Subgroups May Benefit from Lower-Dose Radiation Therapy The study found certain patients did not benefit from lower doses of radiation therapy, suggesting the need for molecular selection. Cancer Researchers Discover Novel Inherited Mutation Predisposing Children to Medulloblastoma The researchers identified rare germline loss-of-function variants across the ELP1 gene in 14 percent of pediatric patients in a medulloblastoma subgroup. Aug 30, 2019 Medulloblastoma Single-Cell Study Yields Tumor-Initiating Cell Population Containing Outcome Clues Jul 24, 2019 Medulloblastoma Molecular Subtypes Refined With Single-Cell Transcriptome Data Jul 23, 2019 Pediatric Oncologists Employing Variety of Sequencing Strategies for Treatment, Research Premium May 10, 2018 New Medulloblastoma Predisposition Genes Result in Proposed Screening Guidelines Jul 19, 2017 Integrated Medulloblastoma Genomics Study Reveals Refined View of Tumor Subtypes Apr 10, 2017 Medulloblastoma Marked by Intra-Tumor Mutation Diversity Jan 28, 2016 International Team IDs Epigenetic Differences Between Medulloblastoma Subtypes Jan 13, 2016 Sequencing Study Reveals Substantial Mutational Changes in Medulloblastomas at Diagnosis, Relapse May 9, 2013 In Biology of Genomes Talk, Single-cell Analysis Offers Refined View of Medulloblastoma Jul 25, 2012 Studies Improve Characterization of Childhood Brain Cancer Subtypes Feb 15, 2012 Genome BC Funds $9.8M Project to Identify Subgroups in Medulloblastoma for Personalized Treatment Premium Feb 1, 2012 Genome BC Funds $9.8M Project to Sequence 1K Childhood Brain Tumors Premium Dec 16, 2010 International Team Reports on Genomic Analyses of Pediatric Brain Cancer Breaking News SARS-CoV-2 Mutational Signature Associated With Mutagenic Antiviral Drug Biocartis Restructures Balance Sheet as H1 2023 Revenues Rise 12 Percent Rare Kidney Cancer Genomic Analysis Reveals Potential Target, Suggests Treatment SEC Concludes CareDx Investigation, Recommends No Enforcement Action Streck Quality Controls for DiaSorin's Luminex Sepsis Tests Receive FDA Clearance The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.