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By profiling dozens of gene sequences, researchers narrowed in on seven genes that, when mutated, provide clues to follicular lymphoma outcomes.
Using a method that relied on Affymetrix arrays, researchers found that 38 patients in the trial had gene expression indicating they were in the ABC subtype.
The team found mutations in 17 genes involved in T cell activation and apoptosis, chromatin remodeling, the nuclear factor kappa beta pathway, and DNA damage response.
Clinicians at the recent ASCO noted that more practical and accurate molecular diagnostics are approaching the clinic alongside novel targeted drug regimens.
Researchers from the US and Italy identified relapse-related methylation profiles in diffuse large B-cell lymphoma tumors taken at diagnosis and relapse.
The method could potentially be useful as a companion diagnostic for targeted drug therapies.
The results need to be validated but demonstrate the clinical utility of a more sensitive screen for detecting minimal residual disease.
In Genome Biology this week: miRNAs linked to diffuse large B-cell lymphoma outcomes, database of bird genomes, and more.
In PNAS this week: microRNA catalogue, early mutational events in follicular lymphoma, and more.
The assay could be useful for identifying patients unlikely to respond to therapy and provide an alternative for monitoring therapy response.
In a letter, about two dozen researchers criticize the World Health Organization investigation into the origins of SARS-CoV-2 and call for a new inquiry, the Wall Street Journal reports.
National Geographic reports that nine great apes at the San Diego Zoo have been vaccinated against SARS-CoV-2.
Janet Woodcock, the acting commissioner of the US Food and Drug Administration, speaks with NPR about SARS-CoV-2 testing and vaccines in the US.
In Science this week: genetic study of kidney fibrosis implicates the SOX9-NAV3-YAP1 axis.