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By profiling dozens of gene sequences, researchers narrowed in on seven genes that, when mutated, provide clues to follicular lymphoma outcomes.
Using a method that relied on Affymetrix arrays, researchers found that 38 patients in the trial had gene expression indicating they were in the ABC subtype.
The team found mutations in 17 genes involved in T cell activation and apoptosis, chromatin remodeling, the nuclear factor kappa beta pathway, and DNA damage response.
Clinicians at the recent ASCO noted that more practical and accurate molecular diagnostics are approaching the clinic alongside novel targeted drug regimens.
Researchers from the US and Italy identified relapse-related methylation profiles in diffuse large B-cell lymphoma tumors taken at diagnosis and relapse.
The method could potentially be useful as a companion diagnostic for targeted drug therapies.
The results need to be validated but demonstrate the clinical utility of a more sensitive screen for detecting minimal residual disease.
In Genome Biology this week: miRNAs linked to diffuse large B-cell lymphoma outcomes, database of bird genomes, and more.
In PNAS this week: microRNA catalogue, early mutational events in follicular lymphoma, and more.
The assay could be useful for identifying patients unlikely to respond to therapy and provide an alternative for monitoring therapy response.
New analyses indicate female researchers are publishing less during the coronavirus pandemic than male researchers, according to Nature News.
A study suggests people with the ApoE e4 genotype may be more likely to have severe COVID-19 than those with other genotypes, the Guardian says.
Direct-to-consumer genetic testing companies are searching for a genetic reason for why some people, but not others, become gravely ill with COVID-19, the Detroit Free Press reports.
In PNAS this week: forward genetics-base analysis of retinal development, interactions of T cell receptors with neoantigens in colorectal cancer, and more.