lymphoma

Truncations to PD-L1's 3' untranslated region were detected in a variety of tumor types, apparently increasing expression of the gene and decreasing immune response to it.

Early results of a study suggest at least some recurrent gene mutations differ by breed for dogs affected by B-cell and/or T-cell lymphomas.

Independent analyses on dozens of tumor-normal Sézary syndrome pairs points to frequent alterations in signaling, cell cycle, and epigenetic pathways.

Researchers have sequenced and analyzed more than 50 feral and domestic cats in search of genetic variants involved in specific physical features and forms of disease. 

An NGS-based assay was better at diagnosing CTCL than PCR-based tests, and could distinguish between malignant and benign skin lesions and identify recurrence.

Researchers characterized mutation patterns in mycosis fungoides and Sézary syndrome using a combination of exome sequencing and targeted sequencing.

By profiling dozens of gene sequences, researchers narrowed in on seven genes that, when mutated, provide clues to follicular lymphoma outcomes.

The team found mutations in 17 genes involved in T cell activation and apoptosis, chromatin remodeling, the nuclear factor kappa beta pathway, and DNA damage response.