Truncations to PD-L1's 3' untranslated region were detected in a variety of tumor types, apparently increasing expression of the gene and decreasing immune response to it.
Early results of a study suggest at least some recurrent gene mutations differ by breed for dogs affected by B-cell and/or T-cell lymphomas.
Independent analyses on dozens of tumor-normal Sézary syndrome pairs points to frequent alterations in signaling, cell cycle, and epigenetic pathways.
Researchers have sequenced and analyzed more than 50 feral and domestic cats in search of genetic variants involved in specific physical features and forms of disease.
In Science this week: ancient Ethiopian genome indicates greater Eurasian backflow into Africa, sequencing to diagnose cutaneous T cell lymphoma, and more.
An NGS-based assay was better at diagnosing CTCL than PCR-based tests, and could distinguish between malignant and benign skin lesions and identify recurrence.
Researchers characterized mutation patterns in mycosis fungoides and Sézary syndrome using a combination of exome sequencing and targeted sequencing.
By profiling dozens of gene sequences, researchers narrowed in on seven genes that, when mutated, provide clues to follicular lymphoma outcomes.
Using a method that relied on Affymetrix arrays, researchers found that 38 patients in the trial had gene expression indicating they were in the ABC subtype.
The team found mutations in 17 genes involved in T cell activation and apoptosis, chromatin remodeling, the nuclear factor kappa beta pathway, and DNA damage response.
Following its departure from the European Union, the UK is to implement a fast-track visa program aimed at attracting scientific talent to Britain, according to BBC News.
ScienceInsider reports that researchers in Brazil are concerned that a creationist was chosen to run the agency that oversees graduate study programs there.
The Washington Post reports that researchers are quickly analyzing the coronavirus that has been causing illness and sharing their findings.
In PLOS this week: common variant associated with BMI in Arctic populations, analysis of microRNA markers associated with being born small for gestational age, and more.