Use of the Oncomine Focus Assay led to an expansion of genomic profiling for all guideline-recommend alterations and the identification of a broad set of clinically relevant targets.
Two new studies have uncovered expression-defined T cell subsets that seem to coincide with better or worse outcomes in breast cancer or non-small cell lung cancer.
In PNAS this week: alternative splicing patterns in sunflowers, EGFR inhibitor resistance in lung adenocarcinoma, and more.
The team integrated tumor barcoding, genome editing, and ultra-deep barcode sequencing to interrogate pairwise combinations of tumor suppressor alterations.
In PNAS this week: half-a-dozen Aspergillus sequenced, genetic similarities between friends and classmates, and more.
A new analysis hints that adenocarcinomas or squamous cell carcinomas may have certain overlapping expression patterns, regardless of the tissue of origin.
In PNAS this week: effects of activating KRAS mutations in lung adenocarcinoma, stranded bisulfite sequencing method, and more.
The software takes somatic mutation profiles from individual patients as input and uses them to prioritize relevant mutations and potential treatments.
Exome sequences and copy number patterns suggest lung adenocarcinoma and squamous cell carcinoma are each marked by specific somatic mutations and driver genes.
The consortium will analyze data from patients and mouse models in the first year as part of efforts to find ways of detecting tumors earlier.
Though many details have yet to be worked out, the draft deal for the UK's withdrawal from the EU is giving researchers some hints for what they can expect, Nature News says.
DNA testing has solved a 100-year-old mystery contained in the skull and teeth samples of a now-extinct monkey that once inhabited Jamaica, Gizmodo reports.
As the UN ponders a ban on gene drives, one malaria researcher says there are less dramatic ways to fight the disease in Africa than unleashing GM mosquitoes on a whole continent.
In Nature this week: an improved reference genome of the Aedes aegypti mosquito, genomes of four species of truffles, and more.