Ymir Genomics and OHSU will share in any value created by the biomarkers and will jointly publish and validate the biomarkers in a large-scale multi-center study.
The partners will use Namocell's single-cell dispensing tool and Takara's Smart-seq technology to isolate and characterize HepaTx's hepatocyte-like cells.
Although normal tissues with somatic mutations did not necessarily progress to cancer, researchers saw a jump in mutational burden in samples associated with cancer or cirrhosis.
The researchers molecularly characterized cells found in cirrhotic tissue that express genes involved in pro-fibrogenic pathways that could be targeted by drugs.
Researchers characterized new and known cell populations with single-cell transcriptome profiles for nearly 10,400 liver cells, using the data to see changes associated with liver cancer.
Researchers found diagnostically informative single-gene mutations in five of the 19 idiopathic liver diseases cases they assessed with exome sequencing.
