liver disease
GWAS Meta-Analysis Finds Five Genetic Loci Associated With Non-Alcoholic Fatty Liver Disease
In addition to the five disease susceptibility loci, the meta-analysis found a potentially causal effect of lower expression of the LPL gene in adipose tissue.
Chronic Liver Disease Genome Sequences Point to Recurrent Mutations in Metabolic Genes
Metabolic pathway mutations turned up across individuals and liver clones in non-alcoholic fatty liver disease or alcohol-related liver disease patients.
Second Genome, Virginia Commonwealth University Partner on NASH Biomarker Discovery
Second Genome aims to identify a composite biomarker for the noninvasive diagnosis of nonalcoholic steatohepatitis patients with advanced fibrosis.
Blood, Urine Biomarker Study Leads to Linked Loci, Disease-Related Risk Scores
By uncovering genetic factors behind blood and urine biomarkers, researchers came up with polygenic scores related to biomarker status and related disease risk.
Nonalcoholic Fatty Liver Disease Progression Can Be Traced by Gene Expression Signature
A transcriptomic study found 25 genes that are differentially expressed at various disease stages, suggesting the proteins they encode could serve as biomarkers.