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liver disease

Clonal Hematopoiesis of Indeterminate Potential Linked to Increased Risk of Chronic Liver Disease

A study of 214,563 individuals from four large cohorts shows CHIP is associated with an elevated risk of liver inflammation and chronic liver disease.

 

Beethoven's Genome Offers Clues to Composer's Liver Disease, Family History

Researchers analyzed DNA from authenticated hair samples of the German composer, identifying liver disease risk variants along with hepatitis B virus sequences.

Nonalcoholic Steatohepatitis Linked to Inflammation-Related Liver Cell Signature

Researchers uncovered a cell adhesion- and migration signature in a subset of NASH hepatocytes, along with expression of an inflammation-related EphB2 receptor tyrosine kinase.

Liver Disease Multiomic Analysis Reveals Detection Clues, Points to Treatment Strategies

Researchers found nonalcoholic fatty liver disease markers with a combination of genome-wide association analyses, blood gene expression profiling, and blood plasma proteomics.

Exome Sequencing Study Uncovers Rare Variants in Gene Protecting Against Liver Disease

The findings of the study, which was funded by Regeneron Pharmaceuticals, suggest a new treatment for conditions like nonalcoholic steatohepatitis (NASH).

Jun 22, 2022

Biosignatures Show Potential For Predicting Cancer Risk in Non-Alcoholic Liver Disease Patients

Jun 8, 2022

Max Planck Team Develops Plasma Proteomic Test for Liver Disease
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Jun 8, 2022

Microbiome, Metabolite Features Can ID People Who May Develop Nonalcoholic Fatty Liver Disease

Jun 3, 2022

Nonalcoholic Fatty Liver Disease Risk Loci Emerge From Multi-Ancestry GWAS

Nov 3, 2021

GWAS Meta-Analysis Finds Five Genetic Loci Associated With Non-Alcoholic Fatty Liver Disease

Oct 13, 2021

Chronic Liver Disease Genome Sequences Point to Recurrent Mutations in Metabolic Genes

Sep 23, 2021

Second Genome, Virginia Commonwealth University Partner on NASH Biomarker Discovery

Jan 19, 2021

Blood, Urine Biomarker Study Leads to Linked Loci, Disease-Related Risk Scores

Dec 2, 2020

Nonalcoholic Fatty Liver Disease Progression Can Be Traced by Gene Expression Signature

Oct 20, 2020

Ymir Genomics Licenses Urine Biomarkers for Liver Disease Detection From OHSU

Apr 29, 2020

DiscernDx Acquires Luminist Labs

Feb 20, 2020

Namocell, Takara Bio, HepaTx Partner on Single-Cell Genomics for Late-Stage Liver Disease

Oct 23, 2019

Mutational Signatures Uncovered in Non-Cancerous Colon, Liver Tissue

Oct 9, 2019

Single-Cell Transcriptome Atlas Gives Peek at Cell Interactions in Liver Cirrhosis

Jul 10, 2019

Liver Cell Atlas Assembled From Single-Cell Transcriptome Data

Apr 15, 2019

Unexplained Liver Disease Cases Diagnosed by Exome Sequencing

Apr 9, 2019

Gut Microbiome Signature to Be Developed as Nonalcoholic Fatty Liver Disease Diagnostic
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Nov 1, 2018

ERS Genomics Licenses CRISPR Tech to DefiniGen for Human Cell Disease Models

Oct 30, 2018

Broad Institute Licenses CRISPR Technology to DefiniGen for Human Cell Disease Models

Jul 12, 2018

Early Efforts to Improve Drug-Induced Liver Injury Detection With Machine Learning Fall Short
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The Scan

RNA Editing in Octopuses Seems to Help Acclimation to Shifts in Water Temperature

A paper in Cell reports that octopuses use RNA editing to help them adjust to different water temperatures.

Topical Compound to Block EGFR Inhibitors May Ease Skin Toxicities, Study Finds

A topical treatment described in Science Translational Medicine may limit skin toxicities seen with EGFR inhibitor therapy.

Dozen Genetic Loci Linked to Preeclampsia Risk in New GWAS

An analysis of genome-wide association study data in JAMA Cardiology finds genetic loci linked to preeclampsia that have ties to blood pressure.

Cancer Survival Linked to Mutational Burden in Pan-Cancer Analysis

A pan-cancer paper appearing in JCO Precision Oncology suggests tumor mutation patterns provide clues for predicting cancer survival that are independent of other prognostic factors.