The assay correlates shortened telomere lengths in patients of different ages to potential risks for inherited diseases, such as bone marrow failure syndrome and liver cancer.
By switching off tumor suppressor genes in immunocompetent mice, the team saw that liver cancer developed and killed the mice within four to five months.
Given the high yield of miRNA markers they were able to isolate, the researchers believe the approach could be commercialized for routine cancer testing.
Researchers have grown tumors in 3D cell cultures to better understand cancer, the Economist reports.
An analysis of new and available liver cancer genomes led to 10 mutational signatures and six structural rearrangement signatures in hepatocellular carcinoma.
Using sequences from hepatocellular carcinomas in Asia, researchers identified numerous cases with mutation signatures linked to aristolochic acid exposure.
Focusing on drugs that appeared to reverse cancer-related gene expression signatures, researchers identified candidate compounds that thwarted cancer cell lines.
In PNAS this week: high-altitude adaptation signature among Tibetans, de novo mutations in early-onset high myopia, and more.
The MIT researchers said that the mutational signature could be used to identify people exposed to aflatoxin who are at risk of developing liver cancer.
The University of California, Los Angeles-led team said the approach outperformed two established classification methods.
A new analysis examines the gender gap among paper authors in the sciences and says it may take decades or more to close.
Researchers have uncovered signals of selection that may enable the Bajau people to free five hundreds of feet deep, Reuters reports.
In Science this week: paternally inherited cis-regulatory structural variants in autism, and more.
A new report outlines issues facing the implementation of personalized medicine in the UK, the Independent reports.