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leishmaniasis

Host Expression Provides Treatment Response Clues in Cutaneous Leishmaniasis

Using RNA sequencing, researchers profiled gene expression patterns in cutaneous leishmaniasis lesions, identifying a handful of genes with treatment-associated expression.

Distinct Parasite Strain, Immune Responses Behind Unusual Leishmaniasis Cases in Brazil

Genetic and immune profiles from Brazilian leishmaniasis cases suggest parasite strain and inflammatory cytokine may contribute to unusual forms of the disease.

Institut Pasteur Korea, DNDi Partner in Neglected Diseases Screening Effort

NEW YORK (GenomeWeb News) – The international non-profit Drugs for Neglected Diseases Initiative (DNDi) and the Institut Pasteur Korea (IP-K) will collaborate to screen for and examine molecules that may be used as new treatments for certain "neglected" diseases, IP-K said today.

Researchers Characterize Genomic Variation in Flesh-Eating Disease Parasites

FDA Approves Leishmaniasis PCR Test Developed by US Army, Cepheid - Update

The assay was developed by the Army Medical Research and Materiel Command in collaboration with the Walter Reed Army Institute of Research and Cepheid under a collaboration begun in 2005.

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The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.