inflammatory disease Multisystem Inflammatory Syndrome in Children Linked to Rare, Immune-Related Variants With exome sequences and clinical data for dozens of Middle Eastern or Asian children, researchers unearthed rare MIS-C-associated variants in immune and other pathways. Endometriosis Treatment Target Proposed From Genetic Analysis Researchers used linkage analyses, targeted sequencing, and genotyping to identify endometriosis-associated variants in a potentially targetable receptor coding gene. Skin Cell Atlas Elucidates Pathological Cell States Underlying Inflammatory Skin Diseases Researchers profiled the transcriptomes of more than 500,000 single cells from human fetal skin and adult skin with atopic dermatitis and psoriasis. Single-Cell Sequencing Reveals Immune Contributors to Exacerbated Asthma in Mouse Model Investigators saw enhanced interleukin-13 production by a handful of immune cell types in mouse models of steroid-resistant asthma. 'Genotype-First' Study Leads to Blood Cell Mutations Underlying Severe Autoinflammatory Disease Premium Since the mutations are only found in a subset of patients' blood cells, the disorder, called VEXAS, might be treatable with a bone marrow transplant. Jul 16, 2020 Rheumatoid Arthritis Flare-Up Clues Found in Blood Transcriptomes Tested Over Time Mar 12, 2020 DIAMONDS Project Using New Classification Approach to Develop Rapid Infectious Disease Tests Premium Feb 3, 2020 IMIDomics, Gossamer Bio Form Immune-Mediated Inflammatory Disease Alliance Jan 20, 2020 Multi-Disease Diagnostic Platform Project Receives €22.5M in EU Funding Apr 11, 2019 Twist Bioscience Providing Antibody Optimization to Pandion Therapeutics for Drug Development Mar 8, 2019 Frontal Fibrosing Alopecia GWAS Implicates Risk Loci with Links to Immune System Jan 30, 2019 iReceptor Plus Consortium Wants to Improve Immunological Data Sharing Premium Jan 15, 2019 Immunological Data Sharing Consortium Wins €8.4M Award From EU, Canada Dec 19, 2018 Inflammatory Bowel Disease, Irritable Bowel Syndrome Show Differences in Gut Microbiomes Jul 28, 2017 Panel Sequencing Leads to Pathogenic Mutations in Autoinflammatory Cases May 31, 2017 IMIDomics, Celgene Partner on Immune-Mediated Inflammatory Disease Research Feb 28, 2017 Centers for Common Disease Genomics Program Standardizes Sequencing Analysis Pipeline Premium Jan 18, 2017 EU Consortium Gets €14M to Personalize Treatment of Inflammatory Diseases Jan 5, 2017 Metabolon, InnVentis Partner to Study Metabolomics in Inflammatory Disease Nov 11, 2015 Team Taps Immune T-Cell Regulators to Find Early Markers of Disease in Blood Apr 24, 2015 Meta-analysis Reveals New Psoriasis Risk Loci in Caucasian, Chinese Populations Feb 2, 2015 Leprosy GWAS Uncovers Risk Variants, Relationship to Inflammatory Disease Jan 29, 2015 Analysis Highlights Strain Diversity in Gut Microbiome Apr 30, 2013 NIAMS to Fund Small Businesses for Inflammatory Disease Biomarker Tools Dec 12, 2012 MDxHealth and Ghent University Begin Collaboration under New Pharmacoepigenomics Center Premium Load More Breaking News Long COVID Clues Found in Acute SARS-CoV-2 Infection Blood Samples People in the News at Roche, Mammoth Biosciences, NeoGenomics, Molecular Assemblies, More New Products Posted to GenomeWeb: Thermo Fisher, Element Biosciences, Dante Genomics, More Tesis Biosciences to Develop miRNA Biomarkers for mTBI Diagnosis In Brief This Week: Danaher, Lucira Health, Novacyt, Molecular Devices The Scan Cell Atlas of Human Lung Development Gives View of Developing Airway Researchers have generated a cell atlas of human lung development, which they report in Cell. Study Finds Costs of Genome Sequencing May Limit Utility in Routine Care Researchers report in the European Journal of Human Genetics that genome sequencing for rare disease diagnoses currently has similar benefits as less expensive exome analysis. Study Suggests Nursing Mother's Diet Can Impact Offspring's Gut Microbiome A new Cell Host and Microbe paper finds that mice whose mothers were fed a low-fiber diet during nursing experience lasting microbiota dysbiosis and increased obesity. Study Links Genetic Risk for ADHD With Alzheimer's Disease A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.