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inflammatory bowel disease

The National Institute of Diabetes and Digestive and Kidney Diseases is planning to fund Genetic Research Centers and a Data Coordinating Center to further knowledge of the genes and variants involved in inflammatory bowel diseases.

After MCW researchers used exome sequencing to provide a diagnosis for a 6-year-old boy with an extreme form of inflammatory bowel disease, the team put in place a broad program to support future clinical sequencing projects. The framework addresses a range of issues that surround diagnostic sequencing — from patient selection to analysis and interpretation, consent and data-sharing policies, and reimbursement.

Researchers from BGI Shenzhen and elsewhere used a metagenomics approach to identify and characterize the microbial genes found in the human gut.

The exclusive sales and marketing agreement covers gene expression tests for inflammatory bowel disease and irritable bowel syndrome.

The company also remains on track with its more advanced familial adenomatous polyposis drug and plans to file within the next two weeks an investigational new drug application to begin testing the therapy in humans.

OSU Medical Center will enroll patients who agree to join Coriell's personalized medicine project under the guidance of their primary care physician. The partners will study the impact of using genomic information in treating chronic conditions.

The technology, called glucan-encapsulated siRNA particles, or GERPs, has been exclusively licensed by RXi Pharmaceuticals for use in developing RNAi-based therapeutics.

Lycera, which is developing drugs for autoimmune diseases, will use the cash to advance through Phase II proof-of-concept studies a drug based on University of Michigan research, and into Phase I trials a second candidate based on research conducted at New York University.

An NIH panel sees wide-ranging needs for genomics, biomarker studies, and new facilities in order to tackle major digestive disorders.

MDRNA also reported its fourth-quarter financial results, posting lower operating costs on the elimination of non-RNAi programs and operations the company was working on prior to a corporate reorganization.

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The Wall Street Journal looks into FamilyTreeDNA's handling of genetic genealogy searches by law enforcement.

In a point-counterpoint in the Boston Globe, researchers discuss the potential of gene editing to prevent Lyme disease, but also the pitfalls of doing so.

MIT's Technology Review reports that researchers hope to develop a CRISPR-based pain therapy.

In Science this week: atlas of malaria parasites' gene expression across their life cycles, and more.