inflammatory bowel disease

Using whole-genome sequence data for thousands of African American individuals, researchers teased out ancestry effects on polygenic risk of the conditions.

The findings further suggested the gut microbiome could influence conditions like inflammatory bowel disease and serve as therapeutic targets.

The researchers also examined the contribution of rare variants to inflammatory bowel disease to find a potential targetable pathway.

The funding will help the San Francisco-based firm apply low-depth NGS as it builds diagnostic tests to aid therapy selection in more diverse populations.

Under the agreement, Israel’s BiomX will generate metagenomic data for gut microbiome samples from IBD patients using its XMarker biomarker discovery platform. 

With single-cell transcriptomic, T cell receptor, and B cell receptor data, researchers tracked immune shifts in tissue and peripheral blood samples from ulcerative colitis patients.

The companies will jointly validate novel drug targets identified by Scipher's molecular interaction network platform for patients with inflammatory bowel disease.

Analyzing genome sequences from dozens of cases and controls, researchers saw an IBD-associated jump in somatic mutations in colonic crypt samples.