A team has identified disease loci for Crohn's and ulcerative colitis using fine mapping alongside high-density genotyping.
The researchers plan to profile patients with both Adaptive Biotechnologies' ImmunoSeq platform and 10x Genomics' single-cell immune repertoire profiling technology.
The firm's recent funding round will support its CLIA-certified laboratory that opened last year and the launch of its first RNA-based diagnostic test.
The Dutch firm expects its product to be the first commercial test on the market to diagnose IBD by analyzing a patient's gut microbiome.
The project aims to elucidate markers of response and non-response to current treatment regimens, and to identify new therapies.
A genome-wide association study of more than 2,700 individuals with Crohn's disease uncovered prognosis-related loci distinct from those linked to disease risk.
In Genome Biology this week: 4C-seq to examine chromatin patterns in IBD, Iberian lynx demographic patterns, and more.
In PNAS this week: genetic variants linked to response to food ads, effects of MECP2 mutations in Rett syndrome, and more.
Based on genetic patterns in thousands of individuals with primary sclerosing cholangitis, researchers identified four new risk loci and explored ties to IBD.
The Norwegian microbiome-focused clinical diagnostics company has ceded commercialization rights in certain undisclosed territories to Bio-Rad as part of the deal.
Technology Review reports that researchers in the US have used CRISPR to modify a number of human embryos.
By introducing genes from butterfly peas and Canterbury bells, researchers in Japan have developed a blue chrysanthemum, according to NPR.
Plant researchers plan to sequence some 10,000 samples that represent the major plant clades, ScienceInsider reports.
In Nature this week: a Danish reference genome, and more.