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immune system diseases

The team identified gene expression patterns that can determine how severe a patient's systemic sclerosis is and if treatment has been effective. 

Researchers working on the Human Functional Genomics Project have begun to unravel genetic relationships and variations in human immune response. 

The company's approach investigates the utility of high-density lipoproteins as molecular markers for multiple diseases, starting with cardiovascular. 

The Human Immunome Program, which is part of the Human Vaccines Project, eventually plans to profile B-cell and T-cell receptors in more than 1,000 individuals.

The new study in NEJM describes six families that share a disorder caused by mutations in IKAROS, a protein that plays a role in immune cell development. 

The partners will identify novel drug targets in cancer, aging, and immune disorders, for which PhoreMost will develop small-molecule therapeutics.

After scrapping initial plans to develop a diagnostic instrument, the company has been working for several years to advance its single-cell droplet platform for targeted drug development.

Researchers have discovered links between disease-associated SNPs for four autoimmune disorders to genes and promoters far away.

Under the arrangement, OMRF will work with Biogen to analyze patient samples and identify biomarkers that indicate responses to particular therapies.

Four bacterial genera are found at lower levels in the gut microbiomes of three-month-old infants believed to be at risk of developing asthma later in life.

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Bioethicists disagree with a research team's decision to allow the return of risk results for adult-onset conditions from a newborn sequencing project, according to Reuters.

Alterations to particular gene may enable the Quechua of Peru to better tolerate high-altitude life, Ars Technica reports.

Nature News reports that additional South Korean researchers have included the names of children on scientific papers when they did not contribute to the work.

In PLOS this week: statistical approach to prioritize rare variant searches, gene expression alterations in chronic obstructive pulmonary disease, and more.