hypertriglyceridemia
23andMe Gains FDA Clearance for Simvastatin Pharmacogenetic Report
The new clearance removes the need for confirmatory testing to use 23andMe's SLCO1B1 report before prescribing simvastatin for hyperlipidemia.
NEW YORK (GenomeWeb) – Alnylam Pharmaceuticals this week announced new preclinical data demonstrating the delivery capabilities of its GalNAc conjugate technology in its hypercholesterolemia and hypertriglyceridemia programs.
The researchers identified an accumulation of rare variants in four genes identified by GWAS. They now plan to sequence more candidate genes using Sanger sequencing and, eventually, next-generation sequencing.
International Team IDs Rare and Common Variants behind Extreme Blood Triglyceride Condition
Using genome-wide association and targeted re-sequencing studies, a Canadian-led research team has uncovered common and rare genetic variants in four genes that are over-represented in individuals with extremely high blood triglyceride levels.