hypertension
Hundreds of Hypertension-Related Effector Genes Identified in Genetic Fine-Mapping Study
Investigators used genetic fine mapping and multiomics to identify 436 blood pressure-related candidate effector genes, some of which could become drug targets.
Blood Pressure Genetic Variants Linked to Regulatory Functions, Cardiovascular Pathways
Using massively parallel reporter assays and other approaches, researchers explored the functional effects of blood pressure-associated variants and narrowed in on causal variants.
Alzheimer's Disease Analysis Leads to Modifiable Causal Factors
Researchers used Mendelian randomization to find causal factors behind Alzheimer's disease, highlighting systolic blood pressure and high-density lipoprotein cholesterol.
Investigators from Inserm and Radboud University Medical Center are spearheading the endeavor, called HT-Advance, which is funded by the EU, the UK, and Switzerland.
Sequencing Data Helps Elucidate Blood Pressure Ties to Rare Sodium Channel Mutations
Based on genome and blood pressure trait data for thousands of individuals, researchers focused in on sodium channel subunits in the kidney and other body tissue.