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PolygenRx Wants to Use Genetics to Guide Chronic Disease Treatments, Starting With Hypertension
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The Australia-based startup wants to partner with drugmakers on biomarker-defined clinical trials and create clinical decision-support software.

Additional Blood Pressure Contributors Uncovered in Large GWAS Meta-Analysis

The loci uncovered in the meta-analysis provided clues to blood pressure biology and enabled the development of new polygenic risk scores.

At ACC, Researchers Showcase New Approaches to Polygenic Risk Scores
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Scores focused on the biochemical pathways associated with disease and pairing these scores with other risk assessments could improve predictive value, the data showed.

Blood Pressure GWAS Highlights Sex-Specific Risk Variants, Links to Cardiovascular Disease

Researchers tracked down 29 new blood pressure-associated genetic loci, along with 1,346 loci linked to the trait in the past.

Hundreds of Hypertension-Related Effector Genes Identified in Genetic Fine-Mapping Study

Investigators used genetic fine mapping and multiomics to identify 436 blood pressure-related candidate effector genes, some of which could become drug targets. 

May 24, 2023

Blood Pressure Genetic Variants Linked to Regulatory Functions, Cardiovascular Pathways

May 17, 2023

Alzheimer's Disease Analysis Leads to Modifiable Causal Factors

Mar 31, 2023

€15M European Project Aims to Pilot New Omics-Based Diagnostics for Hypertension
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Oct 4, 2022

Sequencing Data Helps Elucidate Blood Pressure Ties to Rare Sodium Channel Mutations

Sep 28, 2022

MiRxes Launches Study for Pulmonary Hypertension Biomarkers in Asian Populations

Jul 13, 2022

Family History Improves Polygenic Risk Scores for Complex Disease in Non-Europeans

Aug 12, 2021

Benign Hypertension-Causing Tumors Linked to Somatic Codriver Mutations

Mar 17, 2021

Giraffe Genome Assembly, Functional Analyses Highlight Variants Linked to Height Adaptations

Nov 23, 2020

Rare Variant Study Suggests Blood Pressure Traits May Have Ties to Development, Heart Conditions

Mar 23, 2020

Genetic Risk for High Blood Pressure, Obesity Also Linked to Shorter Lifespan

Jul 31, 2019

Finnish Exomes Yield New Trait, Disease Associations Involving Rare, Deleterious Variants

Apr 17, 2019

Geneticure Launches PGx Test Via Consumer-Facing Model; Pursuing Randomized Trial
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Oct 22, 2018

GeneATLAS Database Documents Diverse Trait Associations Detected With UK Biobank Data

Jun 27, 2018

Lifestyle, Genetics Independently Predict Cardiovascular Disease, Diabetes Risk

Apr 10, 2018

Common Allele Linked to Sugar Consumption Leads to Lower Body Fat, Higher Blood Pressure

Mar 29, 2018

Geisinger PheWAS Uncovers SNPs Associated With Diverse Diseases, Clinical Measurements

Feb 15, 2018

New Blood Pressure Loci Identified in Smoking Status-Informed GWAS

Feb 5, 2018

Chloride Ion Channel Mutations Implicated in Hormone Condition Leading to Hypertension

Dec 5, 2017

Kidney Disease Diagnoses Feasible by Exome Sequencing, Study Finds

Nov 15, 2017

Healthy Gut Microbiome Variation, Disease-Related Declines Described in New Studies