hypercholesterolemia Allelica Wants Polygenic Risk Scores to Become Routine in Heart Disease Care Premium The startup has developed software to automate polygenic risk score generation for hospitals and labs using microarray or sequencing data. Polygenic Variation Affects Disease Risk From Monogenic Variants, Study Finds Accounting for polygenic background in conditions like hereditary breast cancer or Lynch syndrome can increase the accuracy of disease risk estimation. Genetic Screening Identifies Many at Risk of Inherited Disease But Missed by Routine Care Most of the disease risk carriers identified in the Healthy Nevada Project did not meet clinical guidelines for screening, according to the new analysis. American Heart Association Develops Genetic Testing Guidelines for Cardiovascular Disease The AHA said genetic testing is useful in the management of several inherited diseases such as cardiomyopathies and familial hypercholesterolemia. Monogenic Hypercholesterolemia Increases Cardiovascular Disease Risk More Than Polygenic Form Understanding the genetic causes of hypercholesterolemia could provide prognostic information to help treat patients, the researchers said. Jan 9, 2020 Mayo Clinic, Helix Partner for 100K-Patient Clinical Genomics Study Premium Nov 26, 2019 Geisinger Awarded $2.8M Grant for Familial Hypercholesterolemia Research Jul 31, 2019 Finnish Exomes Yield New Trait, Disease Associations Involving Rare, Deleterious Variants Apr 25, 2019 Helix, AdventHealth Partner on Genetic Screening Study Apr 5, 2019 Healthy Nevada Project Identifies Individuals at Risk for Disease That Are Missed by Guidelines Sep 11, 2018 Yale to Launch Large-Scale Genomic Medicine Project Premium May 16, 2018 FH Foundation, Color Launch Familial Hypercholesterolemia Genetic Testing Study Nov 13, 2017 Lipid Nanoparticle CRISPR Delivery Can Result in More Efficient Editing Than Viral Delivery Aug 10, 2017 Color Moves Beyond Hereditary Cancer Testing With High Cholesterol Genetic Test Premium Mar 22, 2016 Admera Health Broadens Test Portfolio With Cardiovascular Additions; Plans Liquid Biopsy Assays Premium Nov 12, 2015 Progenika Biopharma Lands CE Mark for NGS Familial Hypercholesterolemia Test Feb 13, 2015 Alnylam Aims to Release Multi-program Clinical Data in 1H 2015 Premium Dec 12, 2014 Alnylam Begins Clinical Trials of ATTR, Hypercholesterolemia Drugs Premium Nov 13, 2014 Carriers of NPC1L1 Inactivating Mutations Have Lower Coronary Heart Disease Risk, Researchers Say Nov 5, 2014 Study IDs New Loci, Explains 5 Percent of Variation in Cholesterol-Lowering Effects of Statins Premium Oct 30, 2014 Alnylam Files to Begin Phase I Trial of Hypercholesterolemia Drug Premium Sep 30, 2014 Researchers Identify Transcriptomic Signature to Predict Statin Response Sep 24, 2014 Sophia Genetics Gets CE-IVD Mark for Genetic Tests Aug 14, 2014 Alnylam May Seek Approval for TTR Amyloidosis Rx in 2017 as Other Programs Advance Premium May 1, 2014 Alnylam Reports Preclinical Data from Hypercholesterolemia, Hypertriglyceridemia Programs Premium Load More Breaking News Alzheimer's Disease Phosphoproteomics Study Uncovers Signaling Abnormalities Genetic Analysis of H. Pylori Indicates Americas Colonized in One Main Migration Event BillionToOne Raises $55M in Series B Financing GeninCode to Launch Cardiovascular Disease Risk Tests in US With Eversana Top Five Articles on GenomeWeb Last Week: Illumina, Liquid Biopsy, Thermo Fisher Scientific, and More Becton Dickinson Sues Beckman Coulter Over Cell Analysis, Sorting IP The Scan Another Resignation According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug. Novavax Finds Its Vaccine Effective Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19. Can't Be Used The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports. PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.