Huntington's disease
The finding may have implications for therapeutic development, which has long focused on suppressing Huntingtin gene expression but has been largely unsuccessful.
Repeat Expansion Prevalence in Populations Higher Than Assumed, Study Finds
Researchers used genome sequence data for nearly 82,000 individuals to explore RED-related allele frequencies and features across populations.
MilliporeSigma Licenses CRISPR IP to Huntington's Disease Research Nonprofit
The license will allow the nonprofit to edit cell lines and perform other research related to the discovery and development of therapies for Huntington's disease.
Repeat Expansion Disease Diagnosis From Targeted Long Reads Shows Potential for Clinical Use
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Australian researchers have developed a nanopore sequencing test that can detect more than 50 neurological and neuromuscular diseases caused by STR expansions.
Asuragen, Wave Life Sciences to Develop Companion Diagnostics for Huntington's Disease Therapies
Asuragen will use its Amplidex PCR tech to develop companion diagnostics for Wave's investigational allele-selective therapeutic programs for Huntington's.