Huntington's disease
Repeat Expansion Disease Diagnosis From Targeted Long Reads Shows Potential for Clinical Use
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Australian researchers have developed a nanopore sequencing test that can detect more than 50 neurological and neuromuscular diseases caused by STR expansions.
Asuragen, Wave Life Sciences to Develop Companion Diagnostics for Huntington's Disease Therapies
Asuragen will use its Amplidex PCR tech to develop companion diagnostics for Wave's investigational allele-selective therapeutic programs for Huntington's.
The test will run on Oxford Nanopore's MinIon and will be used as a reflex test when the standard PCR test does not give a clear answer.
Systematic CRISPR-Cas9 Analysis Leads to Development of Gene Editing Prediction Tool
The researchers studied edits generated by more than 40,000 gRNAs and gathered data for more than 109 mutational outcomes to create the software.
Huntington Disease Study Leads to Potential MicroRNA Markers in CSF
Six microRNAs appeared to be present at enhanced levels in cerebrospinal fluid from symptom-free individuals with characteristic Huntington disease gene expansions.