HIV

Through a genome-wide association study, an international team of researchers has linked polymorphisms of large effect to host contribution to HIV viral load variation.

The method simplifies previous techniques, and preliminary testing using a microfluidic device indicates it could ultimately be used in low-resource settings.

The scientists fused Cas9 to zinc finger proteins to reduce off-target activity, essentially replacing the other nucleases that had been used with zinc fingers.

Following a beta evaluation of the system, a virology lab in Sheffield, UK, ran a workflow assessment and found improvements with the system.

This Week in PLOS

In PLOS this week: parasitoid wasp sequences in butterflies and moths, nuclear sub-proteome of T. cruzi, and more.

The DxN Veris was recently launched as a CE-marked product with a menu of viral load tests, and will launch in a few years in the US with STD and HAI assays. 

Roche's program will now include early infant HIV diagnostics for low- and middle-income countries.

This Week in Science

In Science this week: reason for partial HIV vaccine protection, and more.

Investigators at the Walter Reed Army Institute and elsewhere identified human leukocyte antigen variants with ties to enhanced or diminished HIV vaccine protection.

The company aims to launch the qPCR-based test in sub-Saharan Africa.

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The World Health Organization has announced the members of its gene-editing committee, according to NPR.

DARPA is working on developing algorithms that gauge the credibility of research findings, Wired reports.

The American Society of Breast Surgeons recommends all women diagnosed with breast cancer be offered genetic testing, the Washington Post says.

In Science this week: comparison of modern, historical rabbit exomes uncovers parallel evolution after myxoma virus exposure; and more.