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NIDA expects to provide $3 million next year for studies using systems biology approaches to explore links between HIV/AIDS and drug use and abuse.

The platform will combine immiscible phase filtration sample prep with automated amplification and detection, and is expected to have initial applications in point-of-care HIV testing in remote and resource-poor areas of the world. The company also sees the platform being used for decentralized molecular testing in more developed countries.

Using a systems biology approach, researchers from Switzerland and the US have identified epistatic interactions involving mutations in two HIV-1 enzymes that can help predict the virus' ability to replicate in the presence or absence of more than a dozen drugs.

The company said this week that it has begun manufacturing prototype disposable test cartridges for performing rapid, inexpensive PCR assays as part of a future portable HIV detection and monitoring system for use in developing countries.

As part of the deal, FIND will have rights to sell the HIV test, as well as Cepheid's Xpert chlamydia and gonorrhea tests, which will be sold at a discount to the public and the not-for-profit sector in some countries.

The protocols enable up to 95 samples to be pooled, resulting in a cost of around $40 per sample, including the cost of reagents, labor, and equipment. The researchers are now using their protocol to sequence the HLA regions of 3,000 HIV-positive individuals.

Nucleic acid testing of blood donations using Gen-Probe's and Novartis' Procleix Ultrio assay revealed a higher-than-expected rate of HBV infection in blood donors, including those who had been previously vaccinated and who would not have been identified by routine antibody screening, according to the study.

The markers could be useful in predicting the incidence of immune reconstitution inflammatory syndrome,an exaggerated inflammatory response that can arise in response to antiretroviral therapy in AIDS patients with cryptococcal meningitis.

A team of researchers from Baylor College of Medicine and University of Texas at Austin have described their strategy for forensically determining the direction of HIV transmission between individuals and identifying index cases.

The Applied Research and Technology Development Award is the single largest amount of non-dilutive funding received by Micronics to date and will help the company add to the menu of tests under development for PanNAT, the company's portable system for nucleic acid amplification-based point-of-care testing.

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Nature News reports that genomics is being applied to trace and try to prevent additional COVID-19 waves.

Rady's Children Hospital and San Diego County are teaming up to test pediatric patients and their families for COVID-19 to gauge the spread of the virus locally, according to the San Diego Union-Tribune.

Wildlife managers aim to boost the genetic diversity of Mexican gray wolves by placing captive-born foster pups into packs with similarly aged wild pups, the Mercury News reports.

In Science this week: Genetic Probability tool identifies likely diagnoses in 45 percent of inflammatory arthritis cases, and more.