Close Menu

HIV

BioMérieux’s NucliSens EasyQ MRSA test; Abbott's RealTime CMV assay; Roche's Cobas TaqScreen MPX Test v2.0; Idaho Tech's Q Fever molecular assay; Gen-Probe's Panther system.

Testing the ability of Roche's 454 GS FLX to detect viral tropism, researchers sequenced the viruses of 14 HIV patients, selecting specifically for the V3 loop of the virus, the region that allows it to infect human immune cells.

According to a paper published in Nature, miR-148a was found to regulate the expression of HLA-C, which plays a key role in immunity, with a variant having been associated with HIV load and progression to AIDS.

NIDA expects to provide $3 million next year for studies using systems biology approaches to explore links between HIV/AIDS and drug use and abuse.

The platform will combine immiscible phase filtration sample prep with automated amplification and detection, and is expected to have initial applications in point-of-care HIV testing in remote and resource-poor areas of the world. The company also sees the platform being used for decentralized molecular testing in more developed countries.

Using a systems biology approach, researchers from Switzerland and the US have identified epistatic interactions involving mutations in two HIV-1 enzymes that can help predict the virus' ability to replicate in the presence or absence of more than a dozen drugs.

The company said this week that it has begun manufacturing prototype disposable test cartridges for performing rapid, inexpensive PCR assays as part of a future portable HIV detection and monitoring system for use in developing countries.

As part of the deal, FIND will have rights to sell the HIV test, as well as Cepheid's Xpert chlamydia and gonorrhea tests, which will be sold at a discount to the public and the not-for-profit sector in some countries.

The protocols enable up to 95 samples to be pooled, resulting in a cost of around $40 per sample, including the cost of reagents, labor, and equipment. The researchers are now using their protocol to sequence the HLA regions of 3,000 HIV-positive individuals.

Nucleic acid testing of blood donations using Gen-Probe's and Novartis' Procleix Ultrio assay revealed a higher-than-expected rate of HBV infection in blood donors, including those who had been previously vaccinated and who would not have been identified by routine antibody screening, according to the study.

Pages

The UK is implementing COVID-19 testing with a 90-minute turnaround time.

The Chan Zuckerberg Biohub is working with California's health department to sequence viral samples from COVID-19 patients to trace viral introductions, according to the San Francisco Chronicle.

Despite differences in their migration habits, eastern and western monarch butterflies are genetically similar, according to a study in Molecular Ecology.

In PLOS this week: identification of fungal species in subcutaneous infections, sequencing of Campylobacter found in raw meat from retail stores, and more.