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Using a systems biology approach, researchers from Switzerland and the US have identified epistatic interactions involving mutations in two HIV-1 enzymes that can help predict the virus' ability to replicate in the presence or absence of more than a dozen drugs.

The company said this week that it has begun manufacturing prototype disposable test cartridges for performing rapid, inexpensive PCR assays as part of a future portable HIV detection and monitoring system for use in developing countries.

As part of the deal, FIND will have rights to sell the HIV test, as well as Cepheid's Xpert chlamydia and gonorrhea tests, which will be sold at a discount to the public and the not-for-profit sector in some countries.

The protocols enable up to 95 samples to be pooled, resulting in a cost of around $40 per sample, including the cost of reagents, labor, and equipment. The researchers are now using their protocol to sequence the HLA regions of 3,000 HIV-positive individuals.

Nucleic acid testing of blood donations using Gen-Probe's and Novartis' Procleix Ultrio assay revealed a higher-than-expected rate of HBV infection in blood donors, including those who had been previously vaccinated and who would not have been identified by routine antibody screening, according to the study.

The markers could be useful in predicting the incidence of immune reconstitution inflammatory syndrome,an exaggerated inflammatory response that can arise in response to antiretroviral therapy in AIDS patients with cryptococcal meningitis.

A team of researchers from Baylor College of Medicine and University of Texas at Austin have described their strategy for forensically determining the direction of HIV transmission between individuals and identifying index cases.

The Applied Research and Technology Development Award is the single largest amount of non-dilutive funding received by Micronics to date and will help the company add to the menu of tests under development for PanNAT, the company's portable system for nucleic acid amplification-based point-of-care testing.

The firm is developing a rapid molecular diagnostic system for potential use in the battlefield.

The companies also said that they have separately resolved a lawsuit filed by Abbott against Qiagen earlier this year related to intellectual property surrounding PCR-based methods for detecting human papillomavirus.

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An initial analysis suggests the novel coronavirus from Wuhan that is sickening people might come from snakes, a team of virologists writes at the Conversation.

DNA testing confirms captured Chicago coyote same as the one that bit a boy near a nature museum, the Chicago Tribune reports.

An analysis of Tibetan ice cores uncovers more than two dozen previously unknown virus groups, LiveScience reports.

In Nature this week: genomic analysis of four children buried in Cameroon approximately 3,000 and 8,000 years ago, and more.