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HIV

The tests eligible for the collaboration include a quantitative HIV-1 viral load assay, as well as a qualitative test for active infection and early infant diagnosis.

The assays add to the test menu of Beckman Coulter's DxN Veris molecular diagnostics system.

The method combines array-based DNA synthesis, phage protein display, immunoprecipitation, and high-throughput sequencing.

An array of 15 HIV-1 recombinant protein and associated peptides matched very closely to ELISA results in evaluating the intricacies of associated antibody binding patterns.

The new cartridge-based test runs on the firm's GeneXpert platform and provides a 90-minute molecular diagnosis of HIV in high-risk individuals and infants.

The Phase II grant will provide the company with funding to develop a commercial-ready version of the test.

The HIV test is the first of several NGS-based infectious disease tests the company plans to develop, with a hepatitis C virus test following close behind.

Tests in development for the Alere q include HIV, tuberculosis, and Ebola assays, and it will initially be targeted to low-resource settings in the developing world.

The assay is intended for early infant diagnosis of HIV infection.

The fully automated self-confirming assay will simultaneously detect HIV/AIDS antibodies and viral RNA in a single specimen.

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