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heart disease

Genome-wide association studies offer a look at the rare and common contributors to the heart condition, pointing to possible prediction and treatment tools.

Patients who underwent SLCO1B1 testing were able to lower their cholesterol levels similarly to those who did not, indicating that testing does not cause harm.

Exome array-wide association and rare variant-focused genome-wide association meta-analyses led to 87 rare variants with ties to one or more blood pressure traits.

A spontaneous coronary condition that is overrepresented in young women had a polygenic risk score linked to lower-than-usual atherosclerosis-related heart disease risk.

Two new papers have identified thousands of genetic loci with ties to more than two-dozen blood cell traits in individuals from up to five ancestry groups.

With a three-pronged approach, a team led by Mount Sinai researchers examined the functional effects of noncoding de novo mutations on cardiac development.

Heart Disease Edits

The New York Times reports on an effort to use gene editing to treat high cholesterol and triglyceride levels in monkeys.

Researchers identified secondary or incidental findings in just over 3 percent of the nearly 22,000 EMERGE III participants, who were profiled with a 109-gene panel.

A GWAS that incorporated magnetic resonance imaging data for UK Biobank participants led to 45 previously undetected risk loci related to dilated cardiomyopathy.

Scoring the Risk

Discover writes that polygenic risk scores could help identify people at risk of disease who might not be spotted using traditional risk factors.

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Politico reports that the NYPD DNA database has grown since it announced it would be removing profiles from it.

Forbes reports that a structural biology lab at Oxford University studying the coronavirus was hacked.

Science reports that a Dutch research funding agency is combating a ransomware attack.

In Science this week: set of 64 haplotype assemblies from 32 individuals, and more.