glioma
Glioblastoma Transcriptomes Point to Mitochondrial Subtype, Potential Treatment Strategies
Using single-cell and bulk RNA sequence data, investigators identified four pathway-based GBM subtypes, including a mitochondrial subtype that appears to respond to related inhibitors.
Thermo Fisher Scientific, Agios Pharmaceuticals to Codevelop Glioma Companion Diagnostic
Thermo will develop a test using its Oncomine Precision Assay to identify IDH1- and IDH2-positive low-grade glioma patients for treatment with Agios' vorasidenib.
Oncologists Make Progress Toward Showing Utility for Brain Cancer Liquid Biopsy
Presentations at the American Society of Clinical Oncology's virtual annual meeting included new findings relevant to both blood- and spinal fluid-based approaches.
Human Tumor Atlas Network Team Shares Strategy for Tracking Tumor Transitions
A new paper outlines an upcoming effort to trace tumor development and trajectory in time and space using single-cell genetics and other genomic methods.
Glioma Hypermutation May Not Correspond to Checkpoint Immunotherapy Response, Study Suggests
A new analysis suggests hypermutation can occur in some chemotherapy-treated gliomas, producing heterogeneous, mutation-rich tumors with poor response to anti-PD-1 treatment.