In Genome Biology this week: tumor-associated macrophage patterns in glioma, systems epigenomics algorithm, and more.

Many molecularly distinct subgroups emerged from a meta-analysis bringing together more than 1,000 high-grade glioma or diffuse intrinsic pontine glioma cases.

Oncoscape, an open-source data tool developed at Fred Hutchinson Cancer Research Center, will soon be able to produce 3D exome visualizations on commercial VR headsets.

A multi-region analysis of medulloblastoma and other tumor types highlighted the dramatic somatic alteration differences that can crop up within a single tumor.

This Week in Science

In Science this week: sequencing study of IDH glioma origins, and more.

Genetic mutations and tumor microenvironment largely account for differences between IDH-A and IDH-O gliomas, the researchers also said.

This Week in Nature

In Nature this week: glioma GWAS uncovers new risk loci, and more.

For the first time, the researchers also found a clear difference in risk factors for high-grade glioblastoma versus low-grade glioma.

Mutation and expression patterns in longitudinal, multifocal, and solitary tumor samples suggest glioblastoma follows a multiverse model of evolution.

In lower-grade glioma tumors lacking three known biomarkers, investigators identified TP53 and H3.3 histone mutations that appear to be linked to poor outcomes.


360Dx reports that the US Centers for Medicare & Medicaid Services would cover next-generation sequencing-based cancer panel tests.

The Washington Post reports that a meteorologist is being considered as presidential science and technology advisor.

In PNAS this week: precision medicine strategy to screen for disease risk, genome evolution in Haemophilus influenzae, and more.

Researchers have developed a PCR-based assay to gauge whether manatees are present in waters.