The goal is to identify patient-specific rearrangements in the primary tumor, and then check for the presence of that rearrangement in the patient's blood during treatment in order to determine tumor progression and monitor therapy response.
Using microarray analyses, researchers have detected a stem cell-related gene expression pattern in an aggressive subtype of glioblastoma multiforme that involves cells expressing the transmembrane protein CD133.
The slew of PGx abstracts presented by the drug giant at the annual oncology meeting highlighted its “focused approach to cancer drug development through the identification and validation of molecular targets,” Pfizer said.
While using stem cells allows Stemina to "make the tissue type of interest. It's an all-human system," and allows the firm to build "the best potential in vitro environment to study a particular question," its CEO said.