glioblastoma
Glioma Organization Untangled Using Spatial Transcriptomic, Proteomic Profiles
Researchers saw disorganized and structured regions that appeared to reflect hypoxia conditions in glioma, along with five cell state layers within the structured parts of a tumor.
Microenvironments Give Clues to Distinct Immunotherapy Responses in Brain Metastases, Glioblastomas
Investigators found microenvironment differences in checkpoint blockade immunotherapy-treated cases involving brain metastases versus recurrent glioblastoma.
Glioblastoma With Wild-Type TP53 Linked to Potentially Targetable Epigenetic Alteration
With the help of a CRISPR-based screen, researchers linked enhanced activity by the chromatin regulatory gene BRD8 to altered p53 function in cells containing wild-type TP53.
The company has identified numerous immunogenic peptides derived from transposable elements at the surfaces of cancer cells.
Wellcome Leap Launches $55M Program to Develop Disease-Specific Tissue Profiling Platforms
The US nonprofit founded by the UK's Wellcome Trust will fund collaborative research projects to build multiscale and multimodal "tissue time machines."