glioblastoma Glioblastoma With Wild-Type TP53 Linked to Potentially Targetable Epigenetic Alteration With the help of a CRISPR-based screen, researchers linked enhanced activity by the chromatin regulatory gene BRD8 to altered p53 function in cells containing wild-type TP53. Mnemo Therapeutics Identifies Possible New Class of Cancer Therapeutic Target Premium The company has identified numerous immunogenic peptides derived from transposable elements at the surfaces of cancer cells. Wellcome Leap Launches $55M Program to Develop Disease-Specific Tissue Profiling Platforms The US nonprofit founded by the UK's Wellcome Trust will fund collaborative research projects to build multiscale and multimodal "tissue time machines." Glioblastoma Omics Study Highlights Informative Tumor Features, Immune Subtypes Genomic, transcriptomic, proteomic, and post-transcriptional modification features in nearly 100 GBM tumors offered clues to tumor biology, revealing four immune subtypes. Glioblastoma Transcriptomes Point to Mitochondrial Subtype, Potential Treatment Strategies Using single-cell and bulk RNA sequence data, investigators identified four pathway-based GBM subtypes, including a mitochondrial subtype that appears to respond to related inhibitors. Nov 19, 2020 Exceptional Responders Cancer Study Points to Possible Treatment Targets Premium Jul 14, 2020 Glioblastoma Brain Tumor Treatment Strategies Stem From Pharmacogenomic Analysis Jul 8, 2020 Glioblastoma, Developing Brain Cell Populations Show Similarities in Single-Cell RNA-Seq Study Jun 9, 2020 Glioblastoma Genomes Point to Non-Coding Driver Mutations Jun 5, 2020 University of Utah Spinout Eigengene Developing Genome-Wide Signatures for Cancer Diagnostics Premium May 31, 2020 Oncologists Make Progress Toward Showing Utility for Brain Cancer Liquid Biopsy Mar 19, 2020 Imaging Could Help ID Brain Cancer Patients Eligible for Plasma Testing Premium Feb 11, 2020 Biological Dynamics Aims to Boost Adoption of Raw Sample Biomarker Tech Through Microsoft Program Premium Nov 21, 2019 Extrachromosomal Oncogene Amplification Involves Rearrangement of Regulatory Elements Oct 30, 2019 Liquid Biopsy Shows Promise in New Brain Cancer Study Aug 26, 2019 Extracellular Vesicles Provide Biomarkers for Glioblastoma Tumor Subtyping Premium May 7, 2019 Kiyatec Targeting Clinical Oncology Space With 3D Cell Culture Technology Premium Mar 21, 2019 Glioblastoma Driver Mutations Appear Long Before Diagnosis, Evolutionary Analysis Suggests Feb 22, 2019 Expression-Based Survival Signature Proposed for Glioblastoma Feb 11, 2019 Glioblastoma Markers of Checkpoint Immunotherapy Response Discovered Jan 3, 2019 Glioblastoma Pathway Signatures, Treatment Responses Differ Between Male, Female Patients Nov 9, 2018 National Cancer Institute Awards $4M to Brain Tumor Sequencing Projects Oct 18, 2018 Secondary Glioblastoma Genomics Study Leads to Proposed Treatment Target Aug 28, 2018 Epigenetics of Glioblastoma Progression Characterized with Integrated Data Jul 2, 2018 Cooperation Among Pediatric Brain Cancer Tumor Cell Subpopulations Boosts Tumorigenic Ability Load More Breaking News Bio-Rad Laboratories, Cytek Biosciences Partner on Flow Cytometry Reagents Tecan Inks Deals for NGS Library Prep System With Element Biosciences, Singular Genomics Genomenon, Flagship Biosciences Partner on Biomarker Discovery, Companion Dx Development Velsera to Integrate Arima Genomics Gene Fusion Test in Pierian Clinical Platform Evonetix Raises $24M in Extended Series B Funding Round The Scan Study Points to Tuberculosis Protection by Gaucher Disease Mutation A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds. SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource. Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages. UK Team Presents Genetic, Epigenetic Sequencing Method Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.