glioblastoma
Glioblastoma With Wild-Type TP53 Linked to Potentially Targetable Epigenetic Alteration
With the help of a CRISPR-based screen, researchers linked enhanced activity by the chromatin regulatory gene BRD8 to altered p53 function in cells containing wild-type TP53.
The company has identified numerous immunogenic peptides derived from transposable elements at the surfaces of cancer cells.
Wellcome Leap Launches $55M Program to Develop Disease-Specific Tissue Profiling Platforms
The US nonprofit founded by the UK's Wellcome Trust will fund collaborative research projects to build multiscale and multimodal "tissue time machines."
Glioblastoma Omics Study Highlights Informative Tumor Features, Immune Subtypes
Genomic, transcriptomic, proteomic, and post-transcriptional modification features in nearly 100 GBM tumors offered clues to tumor biology, revealing four immune subtypes.
Glioblastoma Transcriptomes Point to Mitochondrial Subtype, Potential Treatment Strategies
Using single-cell and bulk RNA sequence data, investigators identified four pathway-based GBM subtypes, including a mitochondrial subtype that appears to respond to related inhibitors.