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With UK Biobank and FinnGenn data, researchers tracked down rare changes in the angiopoietin-like 7 gene that coincide with lower glaucoma and intraocular pressure risk.
In PLOS this week: gene alteration linked to glaucoma, genome sequencing traces origin of lager yeast, and more.
The new PRS could help identify people at increased risk who may benefit from earlier screening and treatment to prevent blindness.
The test will be designed to detect a protein biomarker in aqueous humor that can be used to determine the severity of glaucoma and to make treatment decisions.
Through a meta-analysis of nearly 140,000 people, an international team of researchers tied 112 loci to increased intraocular pressure, a glaucoma risk factor.
The biomarker has been associated with retinal ganglion cell death and is upregulated in mouse models of chronic glaucoma.
In PNAS this week: innate immune interactions with TB bug, cytoplasmic microtubule organizing center-like structure, and more.
Researchers have used the gene-editing tool to disrupt a gain-of-function mutation in mice and human tissues that leads to glaucoma.
Researchers linked loci near three genes, including one involved in limiting oxidative damage, to primary open-angle glaucoma susceptibility.
Through genetic association and functional studies, researchers from the University of California, San Diego found that risk variants in SIX6 and p16INK4a are associated with senescence of retinal ganglion cells.
The Washington Post reports that the CDC's SARS-CoV-2 test issues reflect earlier ones it had with Zika virus testing.
NPR writes that even with thousands of new COVID-19 papers, each should be evaluated based on its own quality.
Researchers traced a gene cluster linked to COVID-19 severity to Neanderthals, the New York Times reports.
In PNAS this week: soil bacteria-derived small molecules affect centrosomal protein, microfluidics approach for capturing circulating tumor cells, and more.