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gastric cancer

In PNAS this week: gene mutations linked to gastric cancer development, genetic determinants that influence reward processing, and more.

The three organizations are inviting comment from health professionals on the recommendations.

In Science this week: immunogenic mutations in GI cancers, and more.

Along with breast, ovarian, and pancreatic cancers, the "signature 3" mutation pattern was detected in around 10 percent of sequenced gastric tumors.

In PNAS this week: regenerative flatworm genome, transmission patterns of autism-linked de novo mutations, and more.

The researchers used a method known as paired-end tag sequencing, or DNA-PET, to identify five recurrent gene fusions in Asian populations with gastric cancer.

New loss-of-function mutations in a gene called ATM were implicated in gastric cancer risk, based on genotyping profiles for thousands of gastric cancer cases and controls in Iceland.

The research may lay the groundwork for a noninvasive test for GI or other types of cancer without prior knowledge of which organ is affected.

The research also uncovered other mutations that might be associated with these cancers in patients who do not have a CDH1 mutation.

The agreement expands the partners' alliance to include additional diseases within the gastrointestinal tract.

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