drug abuse

After a series of duplication and rearrangement events, the genes involved in two key pathways producing morphine, codeine, and noscapine have clustered in the genome.

The university is marshaling the expertise across all its schools in studying myriad factors that might contribute to opioid response, addiction, and abuse.

Researchers suggest that genetic variations could influence the side effects people experience when using synthetic cannabinoids, the International Business Times reports.

The clinical trial is designed to validate that biomarkers, measured in routine urine tests, effectively predict genetic mutations in drug-metabolizing enzymes.

A genome-wide association study of participants from three substance dependence cohorts led to variants in some of the same genes linked to psychiatric disease.

The bespoke array, designed in tandem with Affymetrix, has nearly 650,000 markers to look at genes associated with addiction in several population groups.

NEW YORK (GenomeWeb) – The University of Chicago said on Thursday it has been awarded a five-year, $12 million grant from the National Institute on Drug Abuse to create a center of excellence using rats to study the genetics of drug abuse.

NEW YORK (GenomeWeb News) – The National Institutes of Health is planning to fund research into the genetic and epigenetic factors that may promote alcohol and drug co-addiction, according to a funding announcement published this week.

NEW YORK (GenomeWeb News) – The National Institute on Drug Abuse plans to fund new research projects that aim to discover more about the changes that chronic exposure to drugs cause in the brain, including efforts focused on changes at the genetic, molecular, and cellular levels.

NEW YORK (GenomeWeb News) – The National Institute on Drug Abuse sees great potential for applying genetic and genomic knowledge to addiction research, and plans to fund the creation of education programs to train scientists in ways to analyze and use genetic data in addiction research.

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Microsoft co-founder Paul Allen also contributed to brain research, NPR reports.

The New York Times reports on the shifting interpretations of what some genetic variants mean over time.

In Cell this week: investigation of metastatic tumor evolution, more than 16,000 genetic variants introduced into the budding yeast model organism, and more.

MIT's Technology Review reports on Genentech's pursuit of personalized cancer vaccines.