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Genomic data for more than 125,000 individuals uncovered type 2 diabetes risk variants, many appearing at loci identified through common variant association studies.

The researchers plan to use the award to improve upon existing approaches to analysis of longitudinal proteomics data in the context of type I diabetes.

In the study, the partners will perform exome sequencing and whole-genome array genotyping on more than 9,000 individuals with diabetes or with diabetic relatives.

The investment, which will be paid out over the course of five years, comes in part from industry sources.

The portal offers access to genotype, phenotype, and clinical data related to type 2 diabetes as well as computational tools for querying the information. 

In PNAS this week: ties between epigenetic changes and metabolic memory, dromedary domestication patterns, and more.

Initially studying pancreatic tissue, the team also linked their findings to methylation patterns in blood, suggesting the possibility of developing a non-invasive test.

The team said their approach may have several applications, including evaluation of cellular response to therapies, and early diagnosis of diseases like cancer.

Using mass spec analysis of pancreatic β cell extracts, they identified peptides that appeared responsible for T cell responses involved in the disease.

Michael Snyder

Snyder's new book, "Genomics and Personalized Medicine," serves as a primer for patients and doctors, touching on topics from tailored cancer therapy to wearable devices.

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The Los Angeles Times reports that experts say Moderna's investigational COVID-19 vaccine results seem to be a step in the right direction, but that more testing is needed.

The Washington Post reports a new coronavirus data reporting protocol goes around the Centers for Disease Control and Prevention.

The Trump Administration has reversed its policy that could have stripped international students of their visas, the New York Times says.

In Cell this week: proteomic and metabolomic analysis of blood from COVID-19 patients, change in phosphorylation with infection, and more.