diabetes Type 2 Diabetes Mechanisms, Risk Genes Identified in GWAS Meta-Analysis Researchers uncovered candidate risk genes and potential mechanisms and conducted further analyses of proinsulin-associated risk loci. Exome Sequencing Study Identifies Potential Treatment Target for Diabetes Individuals with protein-truncating MAP3K15 variants are less likely to develop diabetes, suggesting it could also be a possible target for managing the disease. Diabetes Polygenic Risk Score Performance Improved by Addition of Rare Variants Researchers found that rare variants linked to type 2 diabetes or related traits can bolster diabetes classifications performed using common variant polygenic risk scores. Genomics PLC to Provide Polygenic Risk Scores for UK's Our Future Health Research Program The company will work in partnership with Our Future Health to generate risk scores for up to 5 million people and to create methods for providing feedback to participants. Family History Improves Polygenic Risk Scores for Complex Disease in Non-Europeans Strategies for predicting complex disease risk with both polygenic and family history clues appeared beneficial for non-European individuals. May 13, 2022 Type 2 Diabetes Multi-Ancestry GWAS Enables Risk Prediction Across Populations Apr 28, 2022 Million Veteran Program Study Links Genetic Variants Related to Severe COVID-19 to Other Conditions Apr 18, 2022 Clinical Polygenic Risk Assay, Reporting Pipeline Shows Promise for Multiple Conditions Premium Apr 13, 2022 Common Disease Polygenic Risk Scores Show Poor Cross-Ancestry Performance Apr 7, 2022 Post-Transplant Diabetes Risk Informed by Polygenic Risk Profiles in Donors, Recipients Mar 24, 2022 New TWAS Method Helps Analyze Data From Multiple Genetic Ancestries Feb 17, 2022 UK Biobank Exome Study Uncovers Rare Variants Contributing to Cardiometabolic Disease, Traits Feb 14, 2022 Cardiometabolic Disease Shows Ties to Depressive Mood, Irrespective of Genetic Risk Nov 5, 2021 Diabetes Subtypes Stem From Distinct Genetic Contributors, Study Suggests Sep 15, 2021 Broad Institute, Novo Nordisk Foundation Launch Center to Study Genomic Mechanisms of Disease Jul 7, 2021 Rare Mutations Associated With Significantly Higher Risk of Type 2 Diabetes in New Study Jun 15, 2021 Type 1 Diabetes GWAS, Fine-Mapping Leads to New Genetic Loci, Potential Drug Targets Jun 1, 2021 GWAS Across Ancestries Uncovers Novel Genetic Loci Linked to Glycemic Traits Apr 27, 2021 Syntegra Teams With Vanderbilt's Nashville Biosciences on Biobank Data Analysis for Drug R&D Mar 31, 2021 Type 1 Diabetes Onset Preceded by Gene Expression Changes Mar 5, 2021 Fauna Bio Gets $373K NIH Grant to Study Animal Genomes for Potential Drug Targets Feb 11, 2021 Global, Local Polynesian Ancestry Influence Disease Risk Among Native Hawaiians Jan 19, 2021 Blood, Urine Biomarker Study Leads to Linked Loci, Disease-Related Risk Scores Oct 7, 2020 Patia Biopharma, Precision Diabetes to Collaborate on Diabetes Biomarker Development Sep 16, 2020 Epigenetic Markers Predict Type 2 Diabetes Patients Who Respond to, Tolerate Metformin Load More Breaking News New Products Posted to GenomeWeb: Qiagen, Thermo Fisher, Bionano Genomics, BillionToOne, More People in the News at Illumina Ventures, Element Biosciences, Epigenomics, Exagen, More Genomic Approaches Boost Rare Disease Diagnoses in Middle Eastern Patient Population GeneDx to Raise $150M in Public and Direct Stock Offerings In Brief This Week: T2 Biosystems, Novacyt, OpGen, Dante Genomics, Nautilus Biotechnology, More The Scan Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups. Genome-Wide Analysis Sheds Light on Genetics of ADHD A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder. MicroRNA Cotargeting Linked to Lupus A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus. Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.