In adults and children with Crohn's, miR-31 was found at higher levels in gut tissue, and the cases marked by lower expression tended to have poorer outcomes.
The companies aim to develop microbiome diagnostic assays for colon cancer and other gastrointestinal diseases including irritable bowel syndrome.
PredictImmune's test relies on a 16-marker panel run using quantitative PCR to stratify Crohn's disease and ulcerative colitis patients according to the severity of their illnesses.
The panel is designed to measure genetic markers in whole-blood samples in order to predict which patients are likely to experience a severe, relapsing form of the disease.
In Science this week: mutations that allow the malaria parasite to evade treatment, and more.
New research suggests that some risky and protective variants in the LRRK2 gene have shared genetic effects in Crohn's disease and Parkinson's disease.
Gut microbiome researchers have identified features associated with everything from Crohn's disease to salt intake, immune activity, and hypertension.
The newly announced Microbiome Immunity Project seeks to discover links between autoimmune diseases and bacteria in and on the human body.
A team has identified disease loci for Crohn's and ulcerative colitis using fine mapping alongside high-density genotyping.
The model incorporates clinical, serological, and gene expression factors, and could be used to tailor treatment choices.
In PLOS this week: grey wolf population genomics, mutations associated with lung adenocarcinoma survival, and more.
An opinion piece at Bloomberg discusses China's stance on genomic research.
Genetic ancestry testing can affect a person's sense of identity, the New York Times Magazine writes.
Nebula Genomics is launching its genome sequencing service for free for people who provide certain information about themselves, the Boston Globe reports.