Using data from the UK Biobank, a Harvard Medical School-led team of researchers has uncovered 15 new loci associated with coronary artery disease.
The international team says its findings may explain the evolutionary reasons for the maintenance of coronary artery disease in human populations.
Researchers found that certain somatic mutations in blood stem cells elevate coronary heart disease risk, likely by accelerating atherosclerosis.
The test is the first offered for the Sgx Clarity system, a fully automated in vitro diagnostic platform leveraging single-molecule counting technology.
The team performed a gene expression analysis to discover the new loci, bringing the total number of known risk loci associated with CAD to 73.
The firm has settled on a set of metabolite biomarkers, along with an algorithm, for its first version of a test for arterial plaque buildup.
The company plans to open a $20 million Series C round in Q2 of this year and launch a study to support a US Food and Drug Administration submission in mid-2018.
By studying variants in PCSK9, researchers reported the therapies targeting the gene would have some of the same effects as statins.
The results of this meta-analysis by University of Cambridge-led team could have implications for LDL-C-lowering therapies.
The developer has presented clinical results that provide a base for completing development of a multi-protein test kit and conducting a clinical trial in advance of FDA submission.
Researchers have sequenced the genome of the depth-dwelling giant squid.
Prosecutors have charged a former Drexel University professor with theft for allegedly spending federal grant money on adult entertainment and other unrelated expenses, according to the Philadelphia Inquirer.
Chris Collins, a former US representative, has been sentenced to more than two years in prison in an insider trading case involving an Australian biotechnology firm, the New York Times reports.
In PNAS this week: Trypanosoma brucei transcripts, estimate of people at risk of inherited retinal disease, and more.