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coronary artery disease

Brazil halts a late-stage clinical trial of a coronavirus vaccine following a report of an adverse reaction in a participant, the Financial Times reports.

Researchers found ancestry-specific risk variants and developed a better polygenic risk score based on a GWAS and subsequent meta-analysis.

A spontaneous coronary condition that is overrepresented in young women had a polygenic risk score linked to lower-than-usual atherosclerosis-related heart disease risk.

Free of Influence

Public health experts call for a transparent COVID-19 vaccine approval process in a letter; the Food and Drug Administration commissioner assures science-based approval.

In PLOS this week: method to detect SARS-CoV-2 directly from swabs, gene expression patterns in Kaposi's sarcoma, and more.

The GWAS of more than 200,000 Japanese individuals across 42 diseases identified 25 novel loci shared between Japanese and European populations.

Trialing It Out

The New York Times reports Pfizer and BioNTech have also started a trial of their mRNA-based vaccine for SARS-CoV-2 in the US.

Although polygenic risk scores for coronary artery disease can slightly improve standard risk assessment tools, the predicted clinical impact remains small.

Ongoing Scripps research into polygenic risk for coronary artery disease now offers remote genetic counseling as well as an Android app.

The researchers believe their findings could be used to change how patients' risk for breast cancer, colon cancer, or heart disease is calculated.

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The Wall Street Journal reports on gaps in COVID-19 testing affecting less affluent urban areas and rural locations.

According to NBC News, new SARS-CoV-2 variants are making it harder for researchers to model the course of the pandemic.

The New York Times reports that experts say President Joe Biden's goal of vaccinating 1 million people a day in the US in the next 100 days is too low a bar.

In Science this week: single-cell lineage tracing technique applied to study lung cancer metastasis, and more.