coronary artery disease
Single-Nucleus Chromatin Accessibility Profiling in Coronary Artery Disease Points to Mechanisms
The researchers analyzed more than 28,000 cells using single-nucleus ATAC-seq to develop an atlas of genome accessibility.
Researchers developed assays to assess PRSs for six common conditions, along with methods for sharing the results with doctors and patients.
Common Disease Polygenic Risk Scores Show Poor Cross-Ancestry Performance
Using data from six international cohorts, researchers explored cross-ancestry transferability of PRSs for heart disease, type 2 diabetes, breast cancer, and prostate cancer.
Cardiometabolic Disease Shows Ties to Depressive Mood, Irrespective of Genetic Risk
Researchers saw an uptick in coronary artery disease, atrial fibrillation, and type 2 diabetes in individuals with frequent depressed mood across polygenic risk scores.
Variant Identified in Amish Population Appears to Protect From Cardiovascular Disease
A rare missense variant in the enzyme-coding gene B4GALT1 is linked to lower coronary artery disease risk and reduced blood LDL cholesterol levels.