coronary artery disease
High PRS Equivalent to Rare Monogenic Risk Variants in Certain Cases in UK Biobank Population
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Current genetic screening programs might miss people with high disease risk as determined by PRS, who likely outnumber pathogenic mutation carriers.
PlaqueTec Raises $8M in Private Financing
The UK-based company is developing a bioinformatics platform to identify in vivo biomarkers of coronary artery disease to enable personalized treatments.
Combination of Polygenic, Social, Clinical Factors Improve Prediction of Heart Disease Risk
A model of these three measures improved heart disease risk predictions over any one measure, researchers reported at the American College of Cardiology meeting.
Genetic Architecture for Comorbid Depression, Coronary Artery Disease Emerges from Study
Genetic and electronic health record analyses suggest patients with both coronary artery disease and depression share variants in genes involved in inflammatory and cardiomyopathy processes.
Coronary Artery Calcification Culprits Uncovered in Sequencing-Based GWAS
With whole-genome sequencing on 22,400 multi-ancestry participants, researchers performed a genome-wide association study leading to a vascular calcification contributor.