coronary artery disease
Polygenic Risk Score, AI Tool May Help Patients Reduce Inherited Heart Disease Risk, Study Suggests
University of Cambridge researchers said at the American College of Cardiology annual meeting that they plan to make the PRS and AI tool publicly available through an online app.
Cardiac-Related Consequences of Alcohol Flushing Genetic Variant Reduced by Drug
With endothelial cells derived from induced pluripotent stem cells, researchers tracked functional changes and potential treatment targets in alcohol flushing variant carriers.
Heart Disease Genes Flagged by Rare Variant Analysis of Spontaneous Coronary Artery Dissection
With exome sequencing, researchers found risky rare variants in genes involved in vascular connective tissue disease, related monogenic conditions, or past association studies.
Sudden Cardiac Death Risk Informed by Genome-Wide Polygenic Score for Heart Disease
In individuals with a history of coronary artery disease (CAD), a polygenic risk score for CAD showed promise for predicting the risk of sudden and/or arrhythmic death.
Single-Nucleus Chromatin Accessibility Profiling in Coronary Artery Disease Points to Mechanisms
The researchers analyzed more than 28,000 cells using single-nucleus ATAC-seq to develop an atlas of genome accessibility.