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Colorectal Cancer

News and reporting on colorectal cancer.

Though Genomic Health's Oncotype Dx colon cancer assay met its primary endpoint in a clinical study, it did not meet a secondary endpoint.

The assay, based on the Oncotype DX platform, met the primary endpoint for determining the likelihood of post-operative disease recurrence in patients with stage II colon cancer, but did not meet the endpoint for the ability to predict benefit from post-operative 5-fluorouracil/leucovorin treatment.

Citing the FDA's handling of KRAS testing for anti-EGFR monoclonal antibodies, the report asserts that in the near term complex genetic tests such as Oncotype DX should be "performed through CLIA labs, and not held up by slow regulatory processes."

Snippets: Apr 1, 2009

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Epigenomics, Response Genetics, Exact Sciences

A group of researchers from Israel and the US report that they have characterized chromosomal abnormalities in different colorectal cancer stages and identified alterations associated with poor outcomes.

The company said that developing the test would be its priority in 2009, putting it on a somewhat accelerated development schedule. Rosetta had originally said the test might not be available until 2010.

New Releases: Mar 25, 2009

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DxS' TheraScreen KRAS Mutation Kit

DxS get EU approval to sell its TheraScreen K-RAS Mutation Kit for use on Roche's LightCycler instrument and licensed rights to related software.

In opening its new translational research lab, Mass General claims to be "the first and only cancer center" to attempt to molecularly profile all cancer patients that present to the facility.

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Researchers are developing a breath test to determine how severe patients' methylmalonic acidemia disease is, FierceBiotech reports.

NPR reports that vaccine developers are working on SARS-CoV-2 vaccines that are easier to store or administer than the current crop.

Reuters reports that France is to recommend that people under 55 who received one dose of AstraZeneca's SARS-CoV-2 vaccine receive a different vaccine for their second dose.