The agency added new pharmacogenetic information to the label of the metastatic colorectal cancer treatment irinotecan regarding heightened risk for grade 4 neutropenia in patients homozygous and heterozygous for the UGT1A1*28 allele.
Researchers from Ghent University and the National University of Ireland have identified and validated a panel of six microRNAs ideal for use as reference genes in PCR-based miRNA expression analysis in colorectal cancer.
In the May issue of Cancer Prevention Research, Steven Lipkin and colleagues reported that in colon cancer cell lines, the protective effect against colorectal cancer was stronger in cells with a particular SNP in the HMGCR gene.
In the study, Amgen researchers and academic collaborators used the Roche 454 Life Sciences platform to sequence nine genes in 320 tumor samples from a clinical trial of the EGFR inhibitor Vectibix. It represents one of the first applications of next-gen sequencing to characterize samples from a clinical trial.
After missing the first-to-market opportunities with KRAS, both Merck KGaA and Amgen are strategically looking into additional gene markers, with the likely aim of being able to launch companion tests to their drugs that are more sensitive and accurate than the competition.