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Colorectal Cancer

News and reporting on colorectal cancer.

The agency added new pharmacogenetic information to the label of the metastatic colorectal cancer treatment irinotecan regarding heightened risk for grade 4 neutropenia in patients homozygous and heterozygous for the UGT1A1*28 allele.

Asuragen will incorporate the mutation into diagnostic test kits and use it in its clinical lab for research and patient testing.

The term sheet agreement with GeneDiagnostics would cover marketing for the ColonSentry in Shanghai, Zhejiang, and Jiangsu.

Researchers from Ghent University and the National University of Ireland have identified and validated a panel of six microRNAs ideal for use as reference genes in PCR-based miRNA expression analysis in colorectal cancer.

The non-exclusive license grants Warnex the right to establish a PCR-based laboratory-developed test for Septin9 and offer colorectal cancer blood testing services in Canada.

In the May issue of Cancer Prevention Research, Steven Lipkin and colleagues reported that in colon cancer cell lines, the protective effect against colorectal cancer was stronger in cells with a particular SNP in the HMGCR gene.

Warnex will produce a laboratory-developed colorectal cancer test and offer it as a testing service in Canada.

In the study, Amgen researchers and academic collaborators used the Roche 454 Life Sciences platform to sequence nine genes in 320 tumor samples from a clinical trial of the EGFR inhibitor Vectibix. It represents one of the first applications of next-gen sequencing to characterize samples from a clinical trial.

After missing the first-to-market opportunities with KRAS, both Merck KGaA and Amgen are strategically looking into additional gene markers, with the likely aim of being able to launch companion tests to their drugs that are more sensitive and accurate than the competition.

The German molecular diagnostics firm brought in revenues of €4.3 million ($5.8 million) for the year as it launched its first test.

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The Chan Zuckerberg Biohub is working with California's health department to sequence viral samples from COVID-19 patients to trace viral introductions, according to the San Francisco Chronicle.

Despite differences in their migration habits, eastern and western monarch butterflies are genetically similar, according to a study in Molecular Ecology.

The UK is implementing COVID-19 testing with a 90-minute turnaround time.

In PLOS this week: identification of fungal species in subcutaneous infections, sequencing of Campylobacter found in raw meat from retail stores, and more.