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Colorectal Cancer

News and reporting on colorectal cancer.

Exact Sciences gains exclusive, worldwide rights to DNA methylation markers, which will be used in the firm's colorectal cancer test.

The test, which amplifies and detects methylated Septin9 DNA from patient plasma samples, has been shown to identify a higher proportion of colorectal cancers than Quest Diagnostics' laboratory-developed test, called ColoVantage; as well as CE-marked in vitro diagnostics offered in Europe by Epigenomics and Abbott.

The Mayo team is evaluating different capture and sequencing techniques for use in molecular diagnostics. In a recent study the researchers tested NimbleGen's capture array with both the Roche 454 GS FLX and Illumina GA. Next up will be Agilent's in-solution capture technique, RainDance's microdroplet PCR technology, and standard PCR enrichment.

Pharmacogenomics Reporter took stock of industry expectations ahead of FDA's upcoming meeting to discuss the agency's strategy for regulating laboratory-developed tests.

The agreement formalizes a marketing partnership with GeneDiagnostics to sell the ColonSentry test in certain parts of China.

Potsdam-based Signature Dx plans to launch by the fourth quarter of this year two array-based in vitro diagnostics for colorectal cancer. The company will first launch the tests in Europe and intends to seek US regulatory approval at an unspecified time in the future.

Signature Dx will use Affy's microarray technology in two tests it is developing for colorectal cancer.

The licensing agreement marks the first time that a company other than Exiqon will use the locked nucleic acid technology to develop diagnostic products.

The agency added new pharmacogenetic information to the label of the metastatic colorectal cancer treatment irinotecan regarding heightened risk for grade 4 neutropenia in patients homozygous and heterozygous for the UGT1A1*28 allele.

Asuragen will incorporate the mutation into diagnostic test kits and use it in its clinical lab for research and patient testing.


Nature News reports that genomics is being applied to trace and try to prevent additional COVID-19 waves.

Rady's Children Hospital and San Diego County are teaming up to test pediatric patients and their families for COVID-19 to gauge the spread of the virus locally, according to the San Diego Union-Tribune.

Wildlife managers aim to boost the genetic diversity of Mexican gray wolves by placing captive-born foster pups into packs with similarly aged wild pups, the Mercury News reports.

In Science this week: Genetic Probability tool identifies likely diagnoses in 45 percent of inflammatory arthritis cases, and more.