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Colorectal Cancer

News and reporting on colorectal cancer.

Recent collaboration agreements between the company and researchers at the Moffitt Cancer Center and the Buck Institute for Research on Aging will further its "intention of building a portfolio of oncology-related assays using selected-reaction monitoring," said an official.

The EU funding to Agendia will support its involvement in two cancer research consortiums focused on using biomarkers in personalized treatments.

The company has begun enrollment for a trial and plans to recruit more than 10,000 patients, between ages 50 and 84, at average risk of colorectal cancer.

Under the extension of a 2009 deal, Quest will make payments to Clinical Genomics to develop and validate molecular tests for the early detection of colorectal cancer.

The study of the firm's Cologuard test is expected to include more than 10,000 patients between the ages of 50 and 84 who are at average risk for developing colorectal cancer.

The work will focus on the development of mass spec assays for measuring signaling and repair pathway proteins for clinical tumor biopsy analysis.

Under the terms of the transaction, DiagnoCure will also advance the development of certain genomic tests for Signal Genetics.

Using custom microarrays and bisulfite sequencing, researchers have garnered evidence of extensive shifts and variability in methylation patterns in the genomes of several types of cancers.

Saladax will use the money to further commercialize its My5-FU assay, which measures levels of 5-flourouracil, a chemotherapy used for colorectal cancer and other solid tumors.

"We will use multiple 'omics' technologies to ask which kinase signaling pathways are activated in colon cancer," an Agendia spokesperson said of the collaboration, which will also provide independent validation of the company's ColoPrint colon cancer recurrence test.

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