colorectal cancer

A multi-omic analysis implicated a handful of transcription factors, along with genes and regulatory RNAs down- and upstream of them, in metastatic colorectal cancer.

Researchers identified 40 new and 55 known risk variants using a GWAS meta-analysis that included low-frequency variants gleaned from genome sequence data.

This Week in Science

In Science this week: single-cell analysis of colorectal cancers finds genome-wide demethylation patterns, and more.

Researchers separately found that the assay had high concordance with other techniques in cancers including colorectal and endometrial carcinomas.

An analysis of matched tumor-normal samples from dozens of colorectal cancer patients pointed to microbiome differences related to mutations and other tumor features.

Test volume for the firm's Cologuard colorectal cancer screening test rose 49 percent year over year during the quarter.

During the meeting, researchers presented studies on combination immunotherapies and the efficacy of giving molecularly-informed treatments earlier in the disease continuum.

The firm plans to conduct a prospective trial of a pan cancer assay and aims to bring another assay focused on colorectal cancer through FDA clearance.

The company presented a poster at the ACG meeting this week that reported over 80 percent sensitivity in a retrospective cohort with a majority of early-stage cancers.

In Genome Biology this week: DNA methylation in soybean accessions, genetic ancestry of Uralic speakers, and more.

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The Washington Post reports on a Federal Bureau of Investigation plan to place rapid DNA analyzers at booking stations around the country.

In an editorial, officials from scientific societies in the US and China call for the international community to develop criteria and standards for human germline editing.

The US National Institutes of Health is to review studies that have received private support for conflicts of interest, according to the New York Times.

In Science this week: the PsychENCODE Consortium reports on the molecular mechanisms of neuropsychiatric disorders, and more.