chromosomal abnormalities Team Presents Optical Genome Mapping Method for Finding Chromosomal Alterations In a pair of new studies, investigators retrospectively identified known chromosomal alterations in samples from individuals with hematological malignancies and other conditions. Arcedi Biotech Introduces NIPT Analyzing DNA From Rare Fetal Cells in Maternal Blood Premium The company is positioning the blood-based test as an alternative to invasive chorionic villus sampling, the current standard in Denmark. CRISPR-Cas9 Genome Editing Can Lead to Extensive Chromosome Rearrangements A study showed that chromothripsis, a mutational process that can lead to congenital disease and cancer, can result from on-target editing with Cas9. Prenatal Diagnosis Society Recommends cfDNA Screening for Autosomal Trisomies in Twin Pregnancies The literature shows high specificity and sensitivity for cfDNA testing in twin pregnancies. It could also be a viable screening option for triplet pregnancies. ACOG Guidelines Recommend NIPT for All Pregnancies Regardless of Risk The organization had previously only recommended the use of noninvasive prenatal testing in individuals 35 and older or with other known risk factors. Aug 17, 2020 Bionano Genomics Expecting Clinical Validation Studies to Drive Platform Adoption Premium Nov 8, 2019 Some Call for Expanded Payor Coverage of NIPS but Reluctance Remains Premium Aug 9, 2019 Illumina Begins Upgrading NIPT Customers to New Version of Test With Genome-Wide Options Premium Mar 29, 2019 Prenatal Testing Decision Making Tied to Women's Aversion to Risk, Ambiguity Nov 13, 2018 Angle to Enter NIPT Market With Rare Cell Isolation Platform Premium Apr 5, 2018 Singlera to Use $60M Funding to Support Launch of IVDs, Research Into Very Early Detection of Cancer Premium Mar 2, 2018 Mosaic Maternal Fragile Site Expansion Adds to List of Variants Causing False-Positive NIPT Results Oct 11, 2017 Natera Validates Panorama NIPT for Twin Pregnancies; Includes Zygosity, Fetal Sex Determination Premium Dec 21, 2016 Size-Based NIPT Approach Helps Clarify Origin of Subchromosomal Abnormalities Premium Nov 22, 2016 NIH Awards Albert Einstein Scientist $7.5M to Study Genetics of Congenital Heart Abnormalities Nov 2, 2016 Fetal Cell-Based Noninvasive Prenatal Testing Advances With Three New Feasibility Studies Premium Jun 14, 2016 CombiMatrix Believes NGS Preimplantation Genetic Screening Test Will Attract New Customers Premium Feb 26, 2016 Sequenom Publishes Clinical Validation of MaterniT Genome Test Jan 28, 2016 Study Supports Use of Sequencing in Clinical Cytogenetics, Pathogenic CNV Detection Jan 15, 2016 UK National Screening Committee Recommends NIPT Evaluation as Part of Existing Program Dec 18, 2015 India's MedGenome Begins Offering Natera's Panorama NIPT Dec 17, 2015 Researchers Say NIPT Has Limited Clinical Utility for Subchromosomal Abnormalities Nov 10, 2015 NIPT for Sub-Chromosomal Abnormalities Dependent on Fetal DNA Fraction, Sequencing Depth Premium Oct 22, 2015 Multiplicom Gets CE-IVD Mark for Clarigo NIPT Aug 18, 2015 CombiMatrix Lands NY State Approval for Prenatal Dx Array Load More Breaking News In Ongoing False Advertising Suit, Judge Allows Natera Counterclaims Against Guardant Health Centogene Strikes Rare Disease Target Discovery Deal With Insilico Medicine Dilated Cardiomyopathy Gene Mutations Point to Possible Therapeutic Strategy Ginkgo Bioworks Acquires Massachusetts COVID-19 Testing Firm Mainz Biomed Taps DCN Dx to Aid European Study of Enhanced ColoAlert Assay Parse Biosciences Partners With Research Instruments for Southeast Asia Distribution The Scan Transplant Tests Edited Pig Kidneys The Associated Press reports a University of Alabama-Birmingham team transplanted genetically modified pig kidneys into a brain-dead human patient. UK Changes Some Gene-Edited Crop Rules A new law may enable gene-edited crops to be sold in the UK within about five years, New Scientist says. Pill Works Against Omicron in Lab Pfizer's antiviral pill to treat SARS-CoV-2 appears to work against the Omicron variant, the Wall Street Journal reports. Nature Papers Find Genetic Risk Factor for Smell, Taste Loss in COVID-19; Analyze TB Granulomas In Nature this week: genome-wide association study find locus linked to the risk COVID-19 patients losing their sense of taste or smell, and more.