carcinoma Cervical Cancer Exomes Point to Potentially Targetable HER, PIK3CA Pathway Changes Exome sequences from dozens of cervical cancer tumor or primary cell line samples revealed recurrent alterations affecting ERBB2/HER2 and PIK3CA pathways. Carcinoma of Unknown Primary Investigators Pursue Molecular Targets to Tailor Treatments Premium A Phase II trial is pursuing molecularly targeted treatments for CUP as a different Phase III trial failed to find benefit for expression-based primary site therapies. Stanford Team Employs 10x Genomics Platform to Find True Source of Cancer-Fighting T Cells Premium Using 10x Genomics' immune profiling and ATAC-seq assays, the researchers upended the notion that cancer-fighting T cells come from within a tumor. Checkpoint Immunotherapy Response Described in Tumors with Gene Fusion-Based Neoantigens Starting with a head and neck cancer patient who showed an impressive response to pembrolizumab, researchers profiled gene fusion neoantigens in several tumor types. Genomic Differences in Pre-Invasive Lung Cancer Lesions May Predict Outcome Researchers traced genomic, epigenomic, and expression features in lung carcinoma in situ cases that regressed or progressed to invasive lung squamous cell carcinomas. May 17, 2018 Several Cancer Types Significantly Tied to Polygenic Risk Scores in New PheWAS Nov 30, 2017 Head and Neck Cancer Characteristics, Subtypes Refined With Single-Cell Transcriptomes Jun 24, 2015 Team Reveals Feasibility of Using DNA in Blood, Saliva to Track Head, Neck Cancers Jun 18, 2015 Researchers Characterize Mutational Landscape of Serous Tubal Intraepithelial Carcinomas Mar 26, 2009 Launch Pad for Rising Stars Premium Mar 10, 2009 Funding Update for Mar 10, 2009 Premium Feb 25, 2009 UK Startup DNA Electronics Developing Handheld Device to Detect Genetic Risk for Drug AEs Premium Breaking News Lifespan Linked to Lower Protein Synthesis Gene Expression Pathogenic Variants in Disease-Causing Genes Have Low Penetrance on Average, Study Finds ESHG Calls Use of Polygenic Risk Scores in Preimplantation Testing Unethical Metagenomi Raises $175M in Series B Financing Round Twist Bioscience, Artisan Development Labs Collaborate on Antibody Discovery, Cell Therapies AnPac Bio Warned by Nasdaq Over Listing Requirement The Scan Sensor to Spot SARS-CoV-2 Exposure Yale researchers have developed a sensor that gauges SARS-CoV-2 exposure, according to the New Haven Register. Watching BA.2 A subtype of the Omicron SARS-CoV-2 variant has been found in a number of countries, the Washington Post says. Vermont Weighs Genetic Discrimination Bill VT Digger reports Vermont legislators are considering a bill to bar insurer from denying customers coverage based on genetic information. PNAS Papers on Convergent Pathogen Effectors, Lineage-Related RNA Mutations, Desiccation-Tolerant Grass In PNAS this week: convergent evolution of pathogen effectors, algorithm to identify cell lineage features, and more.