cancer of unknown primary Cancer Dx Firm C2i Genomics Raises $100M in Financing The company will use the funds to accelerate the clinical development and commercialization of its minimal residual disease detection C2-Intelligence Platform. CRISPR-Cas9 Genome Editing Can Lead to Extensive Chromosome Rearrangements A study showed that chromothripsis, a mutational process that can lead to congenital disease and cancer, can result from on-target editing with Cas9. Caris Shares Data for AI-Driven Tumor Origin Prediction, Hinting at Diagnostic, Patient Benefit Premium Investigators reported that the classifier could correctly predict cancer type with over 94 percent accuracy and highlighted impacts in a commercially tested cohort. GenomeWeb Index Gains 49 Percent in 2020, Outperforming Wider Markets Despite the havoc wreaked by the COVID-19 pandemic on the economy, several companies in the index saw their shares rise by triple-digit percentages last year. M&A Deals in MDx/Omics Research Tools Space Fall 13 Percent in 2020 Premium Although the total number of deals went down in 2020, those deals were worth more compared to 2019 — four of the top five had billion-dollar price tags. Dec 17, 2020 New Rhesus Macaque Reference Genome Holds Potential for Human Disease, Evolution Research Dec 2, 2020 Epigenome Study Maps Hydroxymethylation Across Diverse Human Tissue Types Nov 23, 2020 Broad Institute DepMap Project Could Lead to Development of New Cancer Drugs Premium Nov 17, 2020 Diagnostics Firms, Lab Providers Form Genomic Profiling Coalition Oct 16, 2020 NGS-Based Profiling May Guide Treatment for Patients With Cancers of Unknown Primary Oct 13, 2020 Twist Bioscience, Neogene Therapeutics Partner to Develop Personalized CAR T Cells, TCR Therapies Sep 3, 2020 Oncocyte, Guardian Research Network Partner to Improve Precision Medicine Clinical Trials Aug 6, 2020 Personalis Q2 Revenues Up 23 Percent Jul 8, 2020 Twist Bioscience, Takeda Pharma Partner to Develop Antibodies for Oncology, Rare Diseases Jul 7, 2020 Cancer Research UK, Abcam Partner to Develop Custom Antibodies for Cancer Research Jun 23, 2020 Advanced CRISPR Screens Uncover Possible Novel Targets for Cancer Therapies Premium Jun 2, 2020 Evidence for Targeted Treatment Builds in Cancers of Unknown Primary but Randomized Data Pending Premium May 7, 2020 Personalis Q1 Revenues Up 36 Percent Apr 28, 2020 New Iteration of AACR's Project GENIE Focuses on Real-World Outcomes to Enhance Precision Oncology Premium Apr 16, 2020 Single Error in Cell Division Can Generate Great Complexity in Cancer Genomes Mar 25, 2020 Personalis Q4 Revenues Grow 38 Percent, Full-Year Revenues Up 73 Percent Mar 11, 2020 Microbiome-Based Cancer Dx Emerges From Cancer Genome Atlas Reanalysis Feb 19, 2020 Cancer, Pathology Organizations Developing Clinical Guidelines for MMR, MSI Testing Jan 27, 2020 Johns Hopkins University Opens New Cancer Center With $5M in Mark Foundation Funding Dec 20, 2019 Large Pan-Cancer CRISPR Screens by Broad, Sanger Institutes Show High Concordance Load More Breaking News Centogene Strikes Rare Disease Target Discovery Deal With Insilico Medicine Dilated Cardiomyopathy Gene Mutations Point to Possible Therapeutic Strategy Ginkgo Bioworks Acquires Massachusetts COVID-19 Testing Firm Mainz Biomed Taps DCN Dx to Aid European Study of Enhanced ColoAlert Assay Parse Biosciences Partners With Research Instruments for Southeast Asia Distribution Thermo Fisher, Oncocyte Ink Development, Comarketing Deal for Cancer IVDs The Scan And a Fourth? A fourth dose of the Pfizer-BioNTech SARS-CoV-2 vaccine in an Israeli study increased antibody levels but did not prevent Omicron variant infections, according to the Financial Times. For Better Science Software A virtual institute funded by former Google CEO Eric Schmidt's philanthropy aims to lure software engineers to academia, Science reports. Recommendation Explanations The New York Times writes that the US Centers for Disease Control and Prevention is straining to both make and explain decisions based on limited information. Genome Research Papers on De Novo Mutation Rates, Polyploid Genotyping, Oncogene Epigenomic Translocation In Genome Research this week: de novo mutations rates in hemoglobin subunits, analysis of variant calling methods for polyploid plants, and more.