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brain disease

Protein Biomarker Shows Promise for Early Detection of Parkinsonian Disorders

Using a multiplex immunoassay, investigators identified elevated levels of the enzyme DOPA decarboxylase in patients with Parkinsonian disorders.

Proteomic Study Points to Stretched-Out Synapse Development in Humans

A comparative study suggests synapse formation takes far longer in humans than in mice or macaques, offering clues to potential strengths and vulnerabilities in the human brain.

Study Finds Unique Molecular Profile of Human, Mice Skull Bone Marrow

German researchers who studied human and mouse skull, bone, and brain samples said that the findings could help better diagnose brain diseases.

Transcriptomic Data May Provide New Way to Classify, Compare Brain Disorders

The researchers studied gene expression of disease-related genes among neurotypical brains and found associations that were previously unknown.

Sequencing Study Suggests Mutations Underlying Cerebral Cysts May Inform Severity, Treatment Options

Using parent-child exomes, researchers saw cerebral arachnoid cyst-related de novo variant enrichment in seven genes, offering clues to related symptoms and severity.

Feb 17, 2023

Large-Scale Study Reveals Genetics of White Matter Connections in the Human Brain

Feb 15, 2023

New Cell Culture, Analysis Approach Helps Explain Differences in Zika Virus Susceptibility

Oct 7, 2022

Center for Multiomic Human Brain Atlas to Tackle Methylation, Gene Expression for $500M NIH Project
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Sep 22, 2022

NIH Launches $500M Effort to Map Cells of the Human Brain

May 9, 2022

CNV-Adjusted Analysis Points to Prognostically Informative Meningioma Methylation Groups

Jun 17, 2021

GWAS Reveals New Loci Linked to Brain White Matter Microstructure

Sep 30, 2020

Post-Infectious Hydrocephalus in Ugandan Children Traced Back to Bacterial, Viral Pathogens

Jul 3, 2019

Altered Immune Cell Activity Reported in Aging Mouse, Human Brains

Dec 13, 2018

PsychENCODE Studies Explore Brain Development, Neuropsychiatric Regulatory Features

Sep 13, 2018

Single-Cell Study Explores Transcriptome in Developing Mouse Cerebellum

Jun 21, 2018

Systems Biology Study of Alzheimer's Disease Supports Ties to Virus

Jan 4, 2018

KRAS Mutations Revealed in Rare Vascular Brain Condition

Feb 27, 2017

Mutations in DCC Gene Linked to Multiple Brain Malformation Conditions

Jul 26, 2016

Human Brain Cortex Structures Mediated by Genetic Factors

Jun 23, 2016

Sequencing of Postmortem Brain Reveals Neuronal Subtypes

Oct 25, 2013

Agilent, South Korean Institute Collaborate on Neurometabolomics Research

Apr 11, 2012

Brain-Specific Somatic Mutations Detected in Epilepsy-Causing Overgrowth Condition

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The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.