brain disease Protein Biomarker Shows Promise for Early Detection of Parkinsonian Disorders Using a multiplex immunoassay, investigators identified elevated levels of the enzyme DOPA decarboxylase in patients with Parkinsonian disorders. Proteomic Study Points to Stretched-Out Synapse Development in Humans A comparative study suggests synapse formation takes far longer in humans than in mice or macaques, offering clues to potential strengths and vulnerabilities in the human brain. Study Finds Unique Molecular Profile of Human, Mice Skull Bone Marrow German researchers who studied human and mouse skull, bone, and brain samples said that the findings could help better diagnose brain diseases. Transcriptomic Data May Provide New Way to Classify, Compare Brain Disorders The researchers studied gene expression of disease-related genes among neurotypical brains and found associations that were previously unknown. Sequencing Study Suggests Mutations Underlying Cerebral Cysts May Inform Severity, Treatment Options Using parent-child exomes, researchers saw cerebral arachnoid cyst-related de novo variant enrichment in seven genes, offering clues to related symptoms and severity. Feb 17, 2023 Large-Scale Study Reveals Genetics of White Matter Connections in the Human Brain Feb 15, 2023 New Cell Culture, Analysis Approach Helps Explain Differences in Zika Virus Susceptibility Oct 7, 2022 Center for Multiomic Human Brain Atlas to Tackle Methylation, Gene Expression for $500M NIH Project Premium Sep 22, 2022 NIH Launches $500M Effort to Map Cells of the Human Brain May 9, 2022 CNV-Adjusted Analysis Points to Prognostically Informative Meningioma Methylation Groups Jun 17, 2021 GWAS Reveals New Loci Linked to Brain White Matter Microstructure Sep 30, 2020 Post-Infectious Hydrocephalus in Ugandan Children Traced Back to Bacterial, Viral Pathogens Jul 3, 2019 Altered Immune Cell Activity Reported in Aging Mouse, Human Brains Dec 13, 2018 PsychENCODE Studies Explore Brain Development, Neuropsychiatric Regulatory Features Sep 13, 2018 Single-Cell Study Explores Transcriptome in Developing Mouse Cerebellum Jun 21, 2018 Systems Biology Study of Alzheimer's Disease Supports Ties to Virus Jan 4, 2018 KRAS Mutations Revealed in Rare Vascular Brain Condition Feb 27, 2017 Mutations in DCC Gene Linked to Multiple Brain Malformation Conditions Jul 26, 2016 Human Brain Cortex Structures Mediated by Genetic Factors Jun 23, 2016 Sequencing of Postmortem Brain Reveals Neuronal Subtypes Oct 25, 2013 Agilent, South Korean Institute Collaborate on Neurometabolomics Research Apr 11, 2012 Brain-Specific Somatic Mutations Detected in Epilepsy-Causing Overgrowth Condition Breaking News Genetic Overlap Between Schizophrenia, Cardiovascular Disease Risk Uncovered by GWAS Analysis Evvy Closes $14M Series A for Vaginal Microbiome Testing, Launches Add-on STI Screen Consanguinity Contributes to Common Disease Risk, Study Suggests Ginkgo Bioworks, Pfizer Ink RNA Drug Discovery Deal Worth up to $331M MDxHealth, University of Oxford to Assess Prostate Test for Predicting Localized Treatment Outcomes The Scan Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. Small Study of Gene Editing to Treat Sickle Cell Disease In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.