brain disease Center for Multiomic Human Brain Atlas to Tackle Methylation, Gene Expression for $500M NIH Project Premium The Salk Institute for Biological Studies is leading this effort as a key part of NIH's new BRAIN Initiative Cell Atlas Network. NIH Launches $500M Effort to Map Cells of the Human Brain The BRAIN Initiative Cell Atlas Network (BICAN) will rely heavily on single-cell sequencing and bioinformatics to create brain cell atlases and maps of cell interactions. CNV-Adjusted Analysis Points to Prognostically Informative Meningioma Methylation Groups DNA methylation profiles and other genomic data for more than 550 meningioma tumors helped researchers identify epigenetic subgroups with prognostic features. GWAS Reveals New Loci Linked to Brain White Matter Microstructure Starting with a genome-wide association study, researchers saw genetic contributors to specific white matter tracts, along with related genes, pathways, cell types, and drug targets. Post-Infectious Hydrocephalus in Ugandan Children Traced Back to Bacterial, Viral Pathogens The researchers identified a strain of the bacterium Paenibacillus thiaminolyticus as well as cytomegalovirus among samples from infants with the condition. Jul 3, 2019 Altered Immune Cell Activity Reported in Aging Mouse, Human Brains Dec 13, 2018 PsychENCODE Studies Explore Brain Development, Neuropsychiatric Regulatory Features Sep 13, 2018 Single-Cell Study Explores Transcriptome in Developing Mouse Cerebellum Jun 21, 2018 Systems Biology Study of Alzheimer's Disease Supports Ties to Virus Jan 4, 2018 KRAS Mutations Revealed in Rare Vascular Brain Condition Feb 27, 2017 Mutations in DCC Gene Linked to Multiple Brain Malformation Conditions Jul 26, 2016 Human Brain Cortex Structures Mediated by Genetic Factors Jun 23, 2016 Sequencing of Postmortem Brain Reveals Neuronal Subtypes Oct 25, 2013 Agilent, South Korean Institute Collaborate on Neurometabolomics Research Apr 11, 2012 Brain-Specific Somatic Mutations Detected in Epilepsy-Causing Overgrowth Condition Breaking News Liver Cancers Detected With Parallel Mutation, Methylation Liquid Biopsy Approach In Brief This Week: Biocept, Thermo Fisher, Biodesix, More Biological Dynamics Taps Two Firms to Study Utility, Economics of Pancreatic Cancer Detection Test Lucira Health Molecular COVID/Flu Test Gets FDA Emergency Use Authorization Biocare Medical Acquires Empire Genomics The Scan UK Pilot Study Suggests Digital Pathway May Expand BRCA Testing in Breast Cancer A randomized pilot study in the Journal of Medical Genetics points to similar outcomes for breast cancer patients receiving germline BRCA testing through fully digital or partially digital testing pathways. Survey Sees Genetic Literacy on the Rise, Though Further Education Needed Survey participants appear to have higher genetic familiarity, knowledge, and skills compared to 2013, though 'room for improvement' remains, an AJHG paper finds. Study Reveals Molecular, Clinical Features in Colorectal Cancer Cases Involving Multiple Primary Tumors Researchers compare mismatch repair, microsatellite instability, and tumor mutation burden patterns in synchronous multiple- or single primary colorectal cancers. FarGen Phase One Sequences Exomes of Nearly 500 From Faroe Islands The analysis in the European Journal of Human Genetics finds few rare variants and limited geographic structure among Faroese individuals.