Brain Cancer News and reporting on brain cancer. Brain Metastases Analysis Points to Distinct Tumor Immune Microenvironments, Potential Treatments Researchers conducted an immunogenomic analysis of brain metastases from individuals with primary lung or breast cancer. Glioblastoma With Wild-Type TP53 Linked to Potentially Targetable Epigenetic Alteration With the help of a CRISPR-based screen, researchers linked enhanced activity by the chromatin regulatory gene BRD8 to altered p53 function in cells containing wild-type TP53. Functional Precision Medicine Firm Kiyatec Raises $18M in Series C Funding Round The Clemson University spinout is developing live tissue-based models of cancer cells for use in predicting patients' individual drug responses. Team Untangles Mechanism Behind Noncoding Glioma Risk Variant A SNP on chromosome 8 that increases risk of IDH-mutant low-grade glioma falls in a brain-specific enhancer that alters transcription factor binding and downstream signaling. Medulloblastoma Molecular Studies Point to Cell Origins, Progenitor Differentiation A pair of studies suggest group 3 and group 4 medulloblastoma subtypes stem from alterations affecting the unipolar brush cell lineage in the developing brain's rhombic lip region. Jul 12, 2022 NCCN Publishes First Guidelines for Pediatric Brain Cancer, Recommends Broad NGS Profiling Jul 6, 2022 Structural Variant Study Points to Pediatric Glioma Drivers, Prognostic Features May 2, 2022 Brain Cancer Canada Funds Development of New Dx Sequencing Assay at St. Michael's Hospital Mar 21, 2022 NIH Launches New Childhood Cancer Genomics Program Nov 12, 2021 Childhood Brain Tumors in Crosshairs of New CHOP-led Sequencing Biobank Effort Premium Mar 31, 2021 Biocept Prepares for First FDA Foray With CSF Liquid Biopsy Brain Metastases Assay Premium Mar 10, 2021 Datar Cancer Genetics Obtains CE Mark for Liquid Biopsy Cancer Test Feb 11, 2021 Glioblastoma Omics Study Highlights Informative Tumor Features, Immune Subtypes Jan 11, 2021 Glioblastoma Transcriptomes Point to Mitochondrial Subtype, Potential Treatment Strategies Nov 13, 2020 Biocept Eyes Neuro-Oncology for Future Liquid Biopsy Growth as Testing Lags Amid COVID Pandemic Premium Aug 28, 2020 Tumor Immune Microenvironment Profiling Could Guide Therapy in Pediatric Brain Cancer Aug 11, 2020 Childhood Ependymoma Single-Cell Sequencing Study Reveals New Cellular Subpopulations Jul 14, 2020 Glioblastoma Brain Tumor Treatment Strategies Stem From Pharmacogenomic Analysis Jun 26, 2020 Brain, Kidney Cancer Studies Lay Path for Clinical Application of Epigenetic Liquid Biopsy Method Premium Jun 9, 2020 Glioblastoma Genomes Point to Non-Coding Driver Mutations Jun 5, 2020 University of Utah Spinout Eigengene Developing Genome-Wide Signatures for Cancer Diagnostics Premium May 31, 2020 Oncologists Make Progress Toward Showing Utility for Brain Cancer Liquid Biopsy May 29, 2020 Tumor Microbiome Appears to Vary With Cancer Type Apr 15, 2020 Glioma Hypermutation May Not Correspond to Checkpoint Immunotherapy Response, Study Suggests Apr 13, 2020 Pediatric Low-Grade Glioma Molecular and Clinical Analysis Defines Subtypes That Predict Outcome Load More Breaking News Bio-Rad Laboratories, Cytek Biosciences Partner on Flow Cytometry Reagents Tecan Inks Deals for NGS Library Prep System With Element Biosciences, Singular Genomics Genomenon, Flagship Biosciences Partner on Biomarker Discovery, Companion Dx Development Velsera to Integrate Arima Genomics Gene Fusion Test in Pierian Clinical Platform Evonetix Raises $24M in Extended Series B Funding Round The Scan Study Points to Tuberculosis Protection by Gaucher Disease Mutation A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds. SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource. Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages. UK Team Presents Genetic, Epigenetic Sequencing Method Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.