Brain Cancer
Brain Metastases Analysis Points to Distinct Tumor Immune Microenvironments, Potential Treatments
Researchers conducted an immunogenomic analysis of brain metastases from individuals with primary lung or breast cancer.
Glioblastoma With Wild-Type TP53 Linked to Potentially Targetable Epigenetic Alteration
With the help of a CRISPR-based screen, researchers linked enhanced activity by the chromatin regulatory gene BRD8 to altered p53 function in cells containing wild-type TP53.
Functional Precision Medicine Firm Kiyatec Raises $18M in Series C Funding Round
The Clemson University spinout is developing live tissue-based models of cancer cells for use in predicting patients' individual drug responses.
Team Untangles Mechanism Behind Noncoding Glioma Risk Variant
A SNP on chromosome 8 that increases risk of IDH-mutant low-grade glioma falls in a brain-specific enhancer that alters transcription factor binding and downstream signaling.
Medulloblastoma Molecular Studies Point to Cell Origins, Progenitor Differentiation
A pair of studies suggest group 3 and group 4 medulloblastoma subtypes stem from alterations affecting the unipolar brush cell lineage in the developing brain's rhombic lip region.