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Brain Cancer

News and reporting on brain cancer.

Brain Metastases Analysis Points to Distinct Tumor Immune Microenvironments, Potential Treatments

Researchers conducted an immunogenomic analysis of brain metastases from individuals with primary lung or breast cancer.

Glioblastoma With Wild-Type TP53 Linked to Potentially Targetable Epigenetic Alteration

With the help of a CRISPR-based screen, researchers linked enhanced activity by the chromatin regulatory gene BRD8 to altered p53 function in cells containing wild-type TP53.

Functional Precision Medicine Firm Kiyatec Raises $18M in Series C Funding Round

The Clemson University spinout is developing live tissue-based models of cancer cells for use in predicting patients' individual drug responses.

Team Untangles Mechanism Behind Noncoding Glioma Risk Variant

A SNP on chromosome 8 that increases risk of IDH-mutant low-grade glioma falls in a brain-specific enhancer that alters transcription factor binding and downstream signaling.

Medulloblastoma Molecular Studies Point to Cell Origins, Progenitor Differentiation

A pair of studies suggest group 3 and group 4 medulloblastoma subtypes stem from alterations affecting the unipolar brush cell lineage in the developing brain's rhombic lip region.

Jul 12, 2022

NCCN Publishes First Guidelines for Pediatric Brain Cancer, Recommends Broad NGS Profiling

Jul 6, 2022

Structural Variant Study Points to Pediatric Glioma Drivers, Prognostic Features

May 2, 2022

Brain Cancer Canada Funds Development of New Dx Sequencing Assay at St. Michael's Hospital

Mar 21, 2022

NIH Launches New Childhood Cancer Genomics Program

Nov 12, 2021

Childhood Brain Tumors in Crosshairs of New CHOP-led Sequencing Biobank Effort
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Mar 31, 2021

Biocept Prepares for First FDA Foray With CSF Liquid Biopsy Brain Metastases Assay
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Mar 10, 2021

Datar Cancer Genetics Obtains CE Mark for Liquid Biopsy Cancer Test

Feb 11, 2021

Glioblastoma Omics Study Highlights Informative Tumor Features, Immune Subtypes

Jan 11, 2021

Glioblastoma Transcriptomes Point to Mitochondrial Subtype, Potential Treatment Strategies

Nov 13, 2020

Biocept Eyes Neuro-Oncology for Future Liquid Biopsy Growth as Testing Lags Amid COVID Pandemic
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Aug 28, 2020

Tumor Immune Microenvironment Profiling Could Guide Therapy in Pediatric Brain Cancer

Aug 11, 2020

Childhood Ependymoma Single-Cell Sequencing Study Reveals New Cellular Subpopulations

Jul 14, 2020

Glioblastoma Brain Tumor Treatment Strategies Stem From Pharmacogenomic Analysis

Jun 26, 2020

Brain, Kidney Cancer Studies Lay Path for Clinical Application of Epigenetic Liquid Biopsy Method
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Jun 9, 2020

Glioblastoma Genomes Point to Non-Coding Driver Mutations

Jun 5, 2020

University of Utah Spinout Eigengene Developing Genome-Wide Signatures for Cancer Diagnostics
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May 31, 2020

Oncologists Make Progress Toward Showing Utility for Brain Cancer Liquid Biopsy

May 29, 2020

Tumor Microbiome Appears to Vary With Cancer Type

Apr 15, 2020

Glioma Hypermutation May Not Correspond to Checkpoint Immunotherapy Response, Study Suggests

Apr 13, 2020

Pediatric Low-Grade Glioma Molecular and Clinical Analysis Defines Subtypes That Predict Outcome

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The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.