Two studies described de novo gene mutations involved in autism spectrum disorder and other neurodevelopmental conditions, while weeding out unrelated changes.
In PLOS this week: signs of positive selection at autism-linked variants, gut microbiome difference between active and sedentary women, and more.
In Nature this week: Plasmodium genomes and evolution, novel developmental disorder loci, and more.
In Cell this week: study of circadian rhythms and the gut microbiome, zygotic reprogramming repair processes, and more.
University of Pennsylvania researchers found that patients with autism had a greater mutational burden in essential genes than their unaffected siblings.
In Nature this week: genome-wide transcriptome analysis of brain samples from people with autism spectrum disorder, flounder genome, and more.
The international team of researchers also examined the genetic ties between personality traits and psychiatric disorders.
Using brain samples from individuals with or without autism spectrum disorder, researchers identified H3K27ac histone acetylation marks associated with ASD.
Using mitochondrial sequence data for hundreds of simplex families, investigators found predicted pathogenic heteroplasmic mutations were over-represented.
In Cell this week: double-strand breaks in the mouse genome, metabolomic features of yeast deletion strains, and more.
Nature News reports that gene therapy approaches are tackling sickle cell disease, but that the cost of treatment is a concern.
The Washington Post reports that a US Senate committee voted this week to approve the nomination of Stephen Hahn to lead the Food and Drug Administration.
One gene regulates hundreds of others to influence facial development, according to New Scientist.
In Nature this week: resources for single-cell analysis, little overlap in the microRNAs used by Salmonella and Shigella to infect host cells, and more.