In Nature this week: statistical method for overcoming case-control imbalance issues, and more.
Genome-wide polygenic risk scores highlight those at risk of coronary artery disease, atrial fibrillation, type 2 diabetes, IBD, and breast cancer.
In Nature this week: CRISPR-Cas9 genome editing to generate yeast with minimal chromosomes, atrial fibrillation risk variants, and more.
With data from more than a million people, researchers found 111 new or known atrial fibrillation-related loci, providing clues to the condition's biology.
Using data from the UK Biobank, researchers explored relative contributions that genetics and lifestyle make to cardiovascular disease and diabetes risk.
In PLOS this week: resource to track Mendelian disease-related variants in dogs, microRNAs linked to atrial fibrillation in surgical patients, and more.
The prospective analysis suggests that the approach could help clinicians identify patients at risk of a stroke who could benefit from anticoagulant treatment.
With a two-stage atrial fibrillation GWAS, researchers took a crack at untangling the pathways, regulatory features, and tissue types contributing to the heart condition.
Backed by €19 million in EU funding, the initiative, called BigData@Heart, will create a research platform that could change the way cardiovascular diseases are diagnosed and treated.
In Nature this week: genomic regions affecting parental care in mice, and more.
The UK's Human Fertility and Embryology Authority calls for consumer genetic testing companies to warn customers that testing could uncover family secrets, according to the Guardian.
Researchers have transplanted edited cells into mice that appear to combat cocaine addiction, New Scientist reports.
The New York Times reports that United Nations delegates have been discussing how to govern the genetic resources of the deep sea.
In PNAS this week: analysis of proteolytic enzymes secreted by circulating tumor cells, phylogenetic study of Fv1 evolution, and more.