With RNA sequence data on thousands of individual lung cells, researchers fleshed out new and known cell clusters, before digging into cell state and cellular interaction changes in asthma.
These loci include a known asthma locus at 17q12-q21, but also loci at 8p23 and 8q24 that could be specific to asthma risk among individuals of African ancestry.
The company, which employs 300 people, axed 30 jobs in the US and 25 jobs from its overseas operations as it refocuses on therapeutic development.
The researchers will combine genomic analysis with environmental and mobile device data from 1,200 participants to try to better understand the disease.
The company is marketing the panel, which runs on NanoString Technologies' nCounter System, to chemical and cosmetics firms as a replacement for animal models.
The partners aim to identify genetic factors common to individuals with asthma and asthma-chronic obstructive pulmonary disease overlap syndrome.
The researchers used nasal swabs, RNA sequencing, and machine learning algorithms to identify 90 genes linked to mild to moderate asthma in patients.
In Nature this week: shared genetic architecture for asthma and allergic diseases, and more.
Owlstone will give AstraZeneca access to its Breath Biopsy Services to identify breath-based biomarkers for stratifying and treating asthma and COPD patients.
CU Denver and UC San Francisco teams are independently performing whole-genome sequencing to find genes involved in reduced efficacy of a common bronchodilator drug.
23andMe has a holiday popup shop at a mall and could open additional stores, Bloomberg reports.
By studying koalas and a retrovirus that infects them, researchers may have uncovered a new sort of 'immune response' that occurs at the genomic level, Agence France Presse reports.
NPR reports that the first person in the US given a gene editing-based therapy for a genetic disorder is heading home.
In Science this week: ancient genomes reveal social inequality within individual households, new method for quantifying genetic variation in gene dosage, and more.